Effectiveness of uterus sanitation in cows with oxytetracycline drugs after surgical separation of the placente

The article presents the results of studying the effectiveness of antimicrobial drugs for intrauterine use (foaming tablets) of domestic and foreign production based on the tetracycline antibiotic oxytetracycline when used for sanitation of the uterus of cows after operative treatment of retention placenta. Samples of uterine-vaginal secretions were taken for microbiological studies from cows, which were surgically separated from the dung. The sensitivity of the microflora of the biomaterial to this tetracycline antibiotic was confirmed by the method of diffusion in agar using standard disks with oxytetracycline (30 μg). Staphylococcus aureus, Streptococcus pyogenes, Escherichia coli and Pseudomonas aeruginosa bacteria were isolated and identified from the biomaterial using generally accepted microbiological methods. The minimum inhibitory concentrations (MIC) of oxytetracycline for bacterial isolates were determined by serial dilutions in a liquid nutrient medium. According to the obtained MIC values, a high level of bacteriostatic activity of the antibiotic was established against bacterial isolates, potential causative agents of postpartum endometritis in cows. All cows, which were manually separated placenta, were divided into three groups – two experimental and control – 8 cows in each. The animals of the experimental group were intrauterineally injected with antimicrobial drugs in the form of foaming tablets, the active substance of which is oxytetracycline, in the dose recommended by the manufacturer (2 tablets per animal twice with an interval of 48 hours). Cows of the control group were not given any intrauterine drugs. The use of intrauterine preparations based on oxytetracycline contributed to the prevention of the development of postpartum endometritis in cows and improved their reproductive characteristics.