Influence of age and sex on the diagnostic yield of inherited cardiac conditions in sudden arrhythmic death syndrome decedents
After a SADS death, the diagnostic yield of comprehensive FE, MA, or both in an expert setting can be up to 45% with a combined approach. Females had higher diagnostic yield than males, most notable with LQTS. CPVT and LQTS diagnoses declined with increasing age. These data highlight the relative utility of FE and MA depending on age and sex for determining underlying diagnoses following SADS deaths.
Authors
- Yanushi D. Wijeyeratne (ORCID: https://orcid.org/0000-0003-0656-5769)
- Mary N. Sheppard (ORCID: https://orcid.org/0000-0003-2724-3881)
- Elijah R. Behr (ORCID: https://orcid.org/0000-0002-8731-2853)
- James S. Ware (ORCID: https://orcid.org/0000-0002-6110-5880)
- Aneil Malhotra (ORCID: https://orcid.org/0000-0002-8670-3764)
- Gherardo Finocchiaro (ORCID: https://orcid.org/0000-0001-7531-6286)
- M Tome Esteban
- Efstathios Papatheodorou (ORCID: https://orcid.org/0000-0003-1882-4668)
- Michael Papadakis (ORCID: https://orcid.org/0000-0003-0616-2353)
- Athanasios Bakalakos (ORCID: https://orcid.org/0009-0006-6356-2205)
- Hariharan Raju (ORCID: https://orcid.org/0000-0003-0000-7520)
- Belinda R. Gray (ORCID: https://orcid.org/0000-0002-9966-0329)
- Nicola Whiffin (ORCID: https://orcid.org/0000-0003-1554-6594)
- Sanjay Sharma (ORCID: https://orcid.org/0000-0002-3630-6138)
Institutions
- Manchester Metropolitan University (GB)
- The University of Sydney (AU)
- St Bartholomew's Hospital (GB)
- Centre for Human Genetics (GB)
- St George's, University of London (GB)
- Royal Prince Alfred Hospital (AU)
- St George’s University Hospitals NHS Foundation Trust (GB)
- University of Oxford (GB)
- Lung Institute (US)
- Genomics (United Kingdom) (GB)
- MRC London Institute of Medical Sciences (GB)
- University College London (GB)
- Imperial College London (GB)
- Macquarie University (AU)
Publication Details
- Journal
- European Journal of Preventive Cardiology
- Published
- 2024-12-18
- DOI
- https://doi.org/10.1093/eurjpc/zwae389
- Citations
- 8
- Primary Topic
- Cardiac electrophysiology and arrhythmias
- Type
- article
- Field-Weighted Citation Impact
- 3.22
Funders
- Wellcome Trust
- National Institute for Health and Care Research
- British Heart Foundation
- Imperial College London
- Medical Research Council
- National Health and Medical Research Council