Comparison of Plasma p-tau217 and [ <sup>18</sup> F]FDG-PET for Identifying Alzheimer Disease in People With Early-Onset or Atypical Dementia
Our study provides evidence that plasma p-tau217 has strong discriminative accuracy for AD among patients with early-onset and/or atypical dementia assessed in specialized settings. Future work should replicate these findings in secondary care settings.
Authors
- Serge Gauthier (ORCID: https://orcid.org/0000-0003-4272-3330)
- Bertrand J. Jean‐Claude (ORCID: https://orcid.org/0000-0002-4312-6485)
- Tharick Ali Pascoal (ORCID: https://orcid.org/0000-0001-9057-8014)
- Joseph Therriault (ORCID: https://orcid.org/0000-0002-7826-4781)
- Nicholas James Ashton (ORCID: https://orcid.org/0000-0002-3579-8804)
- Paolo Vitali (ORCID: https://orcid.org/0000-0001-8953-1542)
- Eduardo Rigon Zimmer (ORCID: https://orcid.org/0000-0002-5349-0053)
- Brian M. Gilfix (ORCID: https://orcid.org/0000-0001-5165-7422)
- Kaj Blennow (ORCID: https://orcid.org/0000-0002-1890-4193)
- Jean‐Paul Soucy (ORCID: https://orcid.org/0000-0001-6979-1259)
- Jaime Fernández Arias (ORCID: https://orcid.org/0000-0002-6810-5920)
- Nesrine Rahmouni (ORCID: https://orcid.org/0009-0004-3081-8468)
- Andréa Lessa Benedet (ORCID: https://orcid.org/0000-0001-8219-1741)
- Arthur C. Macedo (ORCID: https://orcid.org/0000-0002-3957-0284)
- Thomas K. Karikari (ORCID: https://orcid.org/0000-0003-1422-4358)
- Tevy Chan (ORCID: https://orcid.org/0009-0001-9134-5949)
- Seyyed Ali Hosseini (ORCID: https://orcid.org/0000-0001-7542-7541)
- Takashi Matsudaira (ORCID: https://orcid.org/0000-0002-6602-1301)
- Karine Provost (ORCID: https://orcid.org/0000-0002-5311-6758)
- Cécile Tissot (ORCID: https://orcid.org/0000-0003-2711-3833)
- Kely Quispialaya (ORCID: https://orcid.org/0009-0000-6982-7143)
- Henrik Zetterberg (ORCID: https://orcid.org/0000-0003-3930-4354)
- Pedro Rosa‐Neto (ORCID: https://orcid.org/0000-0001-9116-1376)
- Yi-Ting Tina Wang
- Antonio Aliaga (ORCID: https://orcid.org/0009-0006-9792-7815)
- Lydia Trudel (ORCID: https://orcid.org/0009-0002-5593-7717)
Institutions
- Montreal Neurological Institute and Hospital (CA)
- Universidade Federal do Rio Grande do Sul (BR)
- University of Wisconsin–Madison (US)
- Lawrence Berkeley National Laboratory (US)
- University of Pittsburgh (US)
- Sahlgrenska University Hospital (SE)
- Hamamatsu University School of Medicine (JP)
- National Epilepsy Center (JP)
- Wallenberg Wood Science Center (SE)
- UK Dementia Research Institute (GB)
- Centre Hospitalier de l’Université de Montréal (CA)
- University College London (GB)
- Pontifícia Universidade Católica do Rio Grande do Sul (BR)
- McGill University (CA)
- University of Gothenburg (SE)
Publication Details
- Journal
- Neurology
- Published
- 2024-12-23
- DOI
- https://doi.org/10.1212/wnl.0000000000210211
- Citations
- 8
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 3.08
Funders
- Canadian Institutes of Health Research