Seroprevalence of SARS-CoV-2 and risk factors for infection among children in Uganda: A serial cross-sectional study
Results indicate that a larger number of children were infected during the Delta and Omicron waves of COVID-19 compared to the Alpha wave. This study is the largest seroprevalence survey in children in Uganda, providing evidence that most children were infected with SARS-CoV-2 before the vaccine was widely available to pediatric populations. Pediatric infections were vastly underreported by case counts, highlighting the importance of seroprevalence surveys in assessing disease burden when testing and reporting rates are limited and many cases are mild or asymptomatic.
Authors
- Samuel Gonahasa (ORCID: https://orcid.org/0000-0003-4865-0718)
- Isaiah Nabende
- Sarah Kiguli (ORCID: https://orcid.org/0000-0002-8764-4161)
- Thomas Katairo (ORCID: https://orcid.org/0000-0002-2002-8911)
- Isaac Ssewanyana
- Jessica Briggs (ORCID: https://orcid.org/0000-0002-8078-3898)
- Irene Bagala
- Gloria Cuu
- Joaniter I. Nankabirwa (ORCID: https://orcid.org/0000-0001-7818-3845)
- Bryan Greenhouse (ORCID: https://orcid.org/0000-0003-0287-9111)
- Martha Nassali
- Patience Nayebare
- Jane Frances Namuganga (ORCID: https://orcid.org/0000-0001-8452-4247)
- Sabrina Bakeera–Kitaka (ORCID: https://orcid.org/0000-0003-2724-8287)
- Stephen Tukwasibwe (ORCID: https://orcid.org/0000-0002-6469-6516)
- Moses R. Kamya
- Grant Dorsey
Institutions
- University of California, San Francisco (US)
- Butabika Hospital (UG)
- Infectious Diseases Research Collaboration (UG)
- Makerere University (UG)
Publication Details
- Journal
- PLoS ONE
- Published
- 2024-12-23
- DOI
- https://doi.org/10.1371/journal.pone.0312554
- Citations
- 1
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 0.39
Funders
- Bill and Melinda Gates Foundation
- Makerere University
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases
- Fogarty International Center