ATRA-induced NEAT1 upregulation promotes autophagy during APL cell granulocytic differentiation
Our study elucidates the critical role of NEAT1-mediated autophagy in the differentiation of APL cells and delineates the molecular mechanism by which upregulation of NEAT1 enhances autophagy. Specifically, NEAT1 binds to the RNA-binding protein TAF15, which in turn stabilizes the mRNA of both ATG10 and ATG12.
Authors
- Yewei Wang (ORCID: https://orcid.org/0000-0002-2213-5198)
- Yafeng Jiang
- Guangsen Zhang (ORCID: https://orcid.org/0000-0002-3812-9892)
- Doudou Tang
- Shangjie Wu (ORCID: https://orcid.org/0000-0003-0702-776X)
- Huihui Wang (ORCID: https://orcid.org/0000-0002-4988-3719)
- Mingjie Chen (ORCID: https://orcid.org/0009-0002-3268-4876)
Institutions
- Central South University (CN)
- Shanghai CASB Biotechnology (China) (CN)
- Second Xiangya Hospital of Central South University (CN)
Publication Details
- Journal
- PLoS ONE
- Published
- 2024-12-23
- DOI
- https://doi.org/10.1371/journal.pone.0316109
- Citations
- 3
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 0.86
Funders
- Health Commission of Hunan Province
- Natural Science Foundation of Hunan Province
- Shanghai Jiao Tong University
- School of Medicine, Shanghai Jiao Tong University
- Health and Family Planning Commission of Hunan Province