Lung cancer immunotherapy: Status quo, problems, and prospects

Introduction . Lung cancer is the leading cause of cancer mortality in men and women. Due to its high prevalence and significant recurrence rate after standard therapy, the search for new methods of lung cancer treating is an urgent task. A promising treatment strategy is immunotherapy that elicit immune response against tumor cells. Objective . Evaluation of the clinical efficacy and prospects for the safe use of immunotherapy in malignant neoplasms of the pleural cavity. Discussion . The introduction of immunotherapeutic approaches, including adoptive cell therapy with tumor-infiltrating lymphocytes (TIL) or CAR-T cells, the development of neoantigen vaccines, oncolytic viruses, in combination with chemotherapy and blockade of immune checkpoints (ICP) have shown optimistic results in preclinical studies and are currently at different stages of clinical trials for safety and efficacy. Conclusions . Immunotherapy of lung cancer is a promising area of adjuvant therapy. For clinical introduction, immunotherapeutic approaches should be further investigated to increase their effectiveness and minimizing side effects by combining different therapies, improving bioengineered and cellular drugs, and reducing the cost of treatment.