Respiratory Viruses in Patients With Hematological Malignancy in Boreal Autumn/Winter 2023–2024: <scp>EPICOVIDEHA</scp>‐<scp>EPIFLUEHA</scp> Report

Community-acquired respiratory viral infections (CARV) significantly impact patients with hematological malignancies (HM), leading to high morbidity and mortality. However, large-scale, real-world data on CARV in these patients is limited. This study analyzed data from the EPICOVIDEHA-EPIFLUEHA registry, focusing on patients with HM diagnosed with CARV during the 2023-2024 autumn-winter season. The study assessed epidemiology, clinical characteristics, risk factors, and outcomes. The study examined 1312 patients with HM diagnosed with CARV during the 2023-2024 autumn-winter season. Of these, 59.5% required hospitalization, with 13.5% needing ICU admission. The overall mortality rate was 10.6%, varying by virus: parainfluenza (21.3%), influenza (8.8%), metapneumovirus (7.1%), RSV (5.9%), or SARS-CoV-2 (5.0%). Poor outcomes were significantly associated with smoking history, severe lymphopenia, secondary bacterial infections, and ICU admission. This study highlights the severe risk CARV poses to patients with HM, especially those undergoing active treatment. The high rates of hospitalization and mortality stress the need for better prevention, early diagnosis, and targeted therapies. Given the severe outcomes with certain viruses like parainfluenza, tailored strategies are crucial to improving patient outcomes in future CARV seasons.

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Publication Details

Journal
American Journal of Hematology
Published
2024-12-23
DOI
https://doi.org/10.1002/ajh.27565
Citations
10
Primary Topic
Respiratory viral infections research
Type
article
Field-Weighted Citation Impact
3.87

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article

Respiratory Viruses in Patients With Hematological Malignancy in Boreal Autumn/Winter 2023–2024: EPICOVIDEHA‐EPIFLUEHA Report

Annarosa Cuccaro, Marianna Criscuolo, Verena Petzer, Elena Arellano et al.
10 citations
American Journal of Hematology
Respiratory viral infections research
3.87
article

Respiratory Viruses in Patients With Hematological Malignancy in Boreal Autumn/Winter 2023–2024: EPICOVIDEHA‐EPIFLUEHA Report

Annarosa Cuccaro, Marianna Criscuolo, Verena Petzer, Elena Arellano, Michelina Dargenio, Nicola Fracchiolla, Ľuboš Drgoňa, Francesco Marchesi, Nikola Pantić, Eleni Gavriilaki, Maria Merelli, Alessandra Romano, Mario Virgilio Papa, Alessandro Limongelli, Marta Callejas‐Charavia, László Imre Pinczés, Tatjana Adžić‐Vukičević, Jorge Labrador, Ditte Stampe Hersby, И. О. Стома, Benjamín Víšek, Sonia Martín‐Pérez, Jens Van Praet, Noha Eisa, Gaëtan Plantefève, Gabriele Magliano, Dominik Georg Friedrich Wolf, Martin Čerňan, Iker Falces‐Romero, Darko Antić, Monika Biernat, Josip Batinić, Alessandro Busca, Milan Navrátil, Chiara M. Cattaneo, Avinash Aujayeb, Pellegrino Musto, Ildefonso Espigado, Livio Pagano, Reham Khedr, Maria Ilaria Del Principe, Francesca Farina, Vladimir Otašević, Carolina Miranda, Ahlam Almasari, Luana Fianchi, Tommaso Francesco Aiello, Nurettin Erben, Simge Erdem, Jiřı́ Mayer, Barbora Weinbergerová, Stefanie K. Gräfe, Jon Salmanton‐García, Sara Brunetti, Julio Dávila, Mariarita Sciumé, Martina Bavastro, Caterina Buquicchio, Claudio Cerchione, Ferenc Magyari, Tobias Lahmer, Nicola Coppola, Joanna Ewa Drozd-Sokolowska, Davide Nappi, Oliver A. Cornely, Lucia Prezioso, Martin Schönlein, Antonio Vena, Joanna Góra, Anna Dąbrowska‐Iwanicka, Alberto López‐García, Milche Cvetanoski, Nicola Sgherza, Raúl Córdoba, Mirjana Mitrović, Monia Marchetti, Amalia Anastasopoulou, Carolina García‐Vidal, Gina Varricchio, Dario Leotta, Romane Prin, С. Н. Хостелиди, Zlate Stojanoski, Andreas Glenthøj, Mario Delia, Donald C. Vinh, Agnieszka Magdziak, Павел Зак, Martijn Bakker, Klára Piukovics, Michail Samarkos, Natasha Čolović, Inmaculada Heras‐Fernando, Patricia García‐Ramírez, Jędrzej Tłusty, Elwira Wojtyniak, Larisa Idrizović, Erica Mackenzie, Yavuz M. Bilgin, Lukas van den Ven
article en
10 citations

Abstract

Community-acquired respiratory viral infections (CARV) significantly impact patients with hematological malignancies (HM), leading to high morbidity and mortality. However, large-scale, real-world data on CARV in these patients is limited. This study analyzed data from the EPICOVIDEHA-EPIFLUEHA registry, focusing on patients with HM diagnosed with CARV during the 2023-2024 autumn-winter season. The study assessed epidemiology, clinical characteristics, risk factors, and outcomes. The study examined 1312 patients with HM diagnosed with CARV during the 2023-2024 autumn-winter season. Of these, 59.5% required hospitalization, with 13.5% needing ICU admission. The overall mortality rate was 10.6%, varying by virus: parainfluenza (21.3%), influenza (8.8%), metapneumovirus (7.1%), RSV (5.9%), or SARS-CoV-2 (5.0%). Poor outcomes were significantly associated with smoking history, severe lymphopenia, secondary bacterial infections, and ICU admission. This study highlights the severe risk CARV poses to patients with HM, especially those undergoing active treatment. The high rates of hospitalization and mortality stress the need for better prevention, early diagnosis, and targeted therapies. Given the severe outcomes with certain viruses like parainfluenza, tailored strategies are crucial to improving patient outcomes in future CARV seasons.

American Journal of HematologyVol. 100(3)
Università Cattolica del Sacro Cuore (IT), University of Rome Tor Vergata (IT), University of Parma (IT), Croatian Chamber of Economy (HR), University of Debrecen (HU), University Medical Center Groningen (NL), University Hospital Centre Zagreb (HR), Innsbruck Medical University (AT), Cairo University (EG), Universität Hamburg (DE), Mansoura University (EG), Gomel State Medical University (BY), University of Cologne (DE), University of Zagreb (HR), University of Ostrava (CZ), Universität Innsbruck (AT), National and Kapodistrian University of Athens (GR), Masaryk University (CZ), University of Szeged (HU), Medical University of Warsaw (PL), Hospital Universitario La Paz (ES), King Faisal Specialist Hospital & Research Centre (SA), Northumbria Healthcare NHS Foundation Trust (GB), Instituto de Salud Carlos III (ES), McGill University Health Centre (CA), Agostino Gemelli University Polyclinic (IT), Copenhagen University Hospital (DK), TUM Klinikum (DE), Rigshospitalet (DK), Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT), Wroclaw Medical University (PL), Azienda Ospedaliera Citta' della Salute e della Scienza di Torino (IT), University Hospital Ostrava (CZ), Düsseldorf University Hospital (DE), Hospital General Universitario Morales Meseguer (ES), Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda (IT), Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IT), Hospital Universitario Rey Juan Carlos (ES), University Hospital Brno (CZ), Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia (IT), Hospital Universitario Príncipe de Asturias (ES), University Hospital Olomouc (CZ), University Medical Center Hamburg-Eppendorf (DE), Hospital Clínic de Barcelona (ES), German Center for Infection Research (DE), Hospital Universitario de Burgos (ES), AZ Sint-Jan (BE), University of Kansas Medical Center (US), Hospital Universitario Fundación Jiménez Díaz (ES), Policlinico Universitario di Catania (IT), IRCCS Ospedale San Raffaele (IT), Instituto de Biomedicina de Sevilla (ES), Centre Hospitalier Victor Dupouy (FR), University Hospital Hradec Králové (CZ), Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (DE), Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale" (IT), PHI University Psychiatric Clinic - Skopje (MK), Ospedale Policlinico San Martino (IT), Ospedale Sant'Anna (IT), The Maria Sklodowska-Curie National Research Institute of Oncology (PL), Admiraal De Ruyter Ziekenhuis (NL), North-Western State Medical University named after I.I. Mechnikov (RU), Ospedale Vito Fazzi (IT), Istituti di Ricovero e Cura a Carattere Scientifico (IT), University Hospital Cologne (DE), G. Papanikolaou General Hospital (GR), Azienda Ospedaliera Nazionale SS. Antonio e Biagio e Cesare Arrigo (IT), Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (ES), Children Cancer Hospital (EG), Hospital Nuestra Señora de Alarcos (ES), Heinrich Heine University Düsseldorf (DE), Eskişehir Osmangazi University (TR), Istanbul University (TR), Universitat de Barcelona (ES), Comenius University Bratislava (SK), Universidad de Sevilla (ES), University of Genoa (IT)
Univerzita Komenského v Bratislave, Deutsches Zentrum für Infektionsforschung, Fakultní nemocnice Hradec Králové, Università degli Studi di Genova, National and Kapodistrian University of Athens, Eskişehir Osmangazi Üniversitesi, Ostravská Univerzita v Ostravě, Università degli Studi di Roma Tor Vergata, Universität zu Köln, Uniwersytet Medyczny im. Piastów Slaskich we Wroclawiu, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Medizinische Universität Innsbruck, Masarykova Univerzita, Universität Innsbruck, Universitätsklinikum Köln, Szegedi Tudományegyetem, Instituto de Salud Carlos III, National Cancer Institute
Good health and well-being
Openalex Percentile: Top 6%
Respiratory viral infections research
3.87
DOIOpen Access PDFOpenAlex
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