Gegen-Sangshen oral liquid and its active fractions mitigate alcoholic liver disease in mice through repairing intestinal epithelial injury and regulating gut microbiota
LGS exerts its anti-ALD effect in mice through regulating gut-liver axis, and its flavonoid and polysaccharide fractions, LGSF and LGSP, are responsible for its protective effect.
Authors
- Wanping Li (ORCID: https://orcid.org/0000-0002-1895-5804)
- Shuai Deng (ORCID: https://orcid.org/0000-0001-7622-2097)
- Xu Wu (ORCID: https://orcid.org/0000-0003-4555-0076)
- Yubin Liu (ORCID: https://orcid.org/0000-0002-5531-6972)
- Long Zhao (ORCID: https://orcid.org/0000-0002-6126-2210)
- Yueshui Zhao (ORCID: https://orcid.org/0000-0002-1972-6130)
- Fukuan Du (ORCID: https://orcid.org/0000-0002-5248-353X)
- Jiayue Yang (ORCID: https://orcid.org/0000-0001-8463-0883)
- Tiangang Wang (ORCID: https://orcid.org/0000-0002-9341-7029)
- Shulin Wei
- Wei Mei (ORCID: https://orcid.org/0000-0002-7834-8643)
- Zhangang Xiao (ORCID: https://orcid.org/0000-0003-3249-1118)
- Xiaobing Li (ORCID: https://orcid.org/0000-0003-2549-3211)
- Yu Chen (ORCID: https://orcid.org/0000-0002-7049-1285)
- Mingxing Li (ORCID: https://orcid.org/0000-0001-5729-3850)
- Yuhong Sun (ORCID: https://orcid.org/0000-0003-1358-989X)
- Zhi Li
- Jing Shen (ORCID: https://orcid.org/0000-0003-0077-9467)
- Ke Wu
- Gu Li (ORCID: https://orcid.org/0009-0001-5007-0723)
Institutions
- Southwest Medical University (CN)
- Affiliated Hospital of Southwest Medical University (CN)
- First Affiliated Hospital of Sichuan Medical University (CN)
- Sichuan Academy of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Chinese Medicine
- Published
- 2024-12-23
- DOI
- https://doi.org/10.1186/s13020-024-01049-y
- Citations
- 5
- Primary Topic
- Alcohol Consumption and Health Effects
- Type
- article
- Field-Weighted Citation Impact
- 2.12
Funders
- Southwest Medical University
- Luzhou Science and Technology Bureau