Copper and DMAP Relay‐Catalyzed Three‐Component coupling of Terminal Alkynes, Anthranils and Alcohols for the Modular Synthesis of 2‐alkoxy Quinolines
Abstract A copper and DMAP relay‐catalyzed strategy has been achieved for the modular synthesis of 2‐alkoxy quinolines from a three‐component coupling of terminal alkynes, anthranils, and alcohols. In this protocol, a novel quinoline pyridine salt is formed and serves as a key intermediate in the formation of 2‐alkoxy quinolines. The reaction has a broad substrate scope of each reaction partners, affording diversified 2‐alkoxy quinoline products in generally good yields.
Authors
- Yanping Huo (ORCID: https://orcid.org/0000-0003-4124-6026)
- Yang Gao (ORCID: https://orcid.org/0000-0001-9270-6251)
- H.Z. Li (ORCID: https://orcid.org/0009-0007-8463-1422)
- Qian Chen (ORCID: https://orcid.org/0000-0002-0818-6028)
- Xianwei Li (ORCID: https://orcid.org/0000-0002-4014-6712)
- Xing Zhong
Institutions
- Guangdong University of Technology (CN)
- Wenzhou Medical University (CN)
- Dongyang People's Hospital (CN)
- South China University of Technology (CN)
Publication Details
- Journal
- Advanced Synthesis & Catalysis
- Published
- 2024-12-23
- DOI
- https://doi.org/10.1002/adsc.202401293
- Citations
- 2
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.50
Funders
- National Natural Science Foundation of China
- Guangdong University of Technology