Hydroxyl chalcone derivative DK02 as a multi‐target‐directed ligand for Alzheimer's disease: A preclinical study in zebrafish
DK02 shows promise as a multi-target-directed ligand for AD, offering a new therapeutic path by simultaneously addressing cholinergic, oxidative and amyloid pathways. Its potential to enhance cognitive functions and curtail neurodegeneration suggests advantages over current symptomatic treatments. Further research into DK02 mechanisms and long-term impacts is essential for its development in AD therapy.
Authors
- S.P. Ramya Ranjan Nayak (ORCID: https://orcid.org/0009-0006-6510-5833)
- Rajakrishnan Rajagopal (ORCID: https://orcid.org/0000-0003-0917-7673)
- Jesu Arockiaraj (ORCID: https://orcid.org/0000-0002-0240-7141)
- M. K. Kathiravan (ORCID: https://orcid.org/0000-0001-8357-2730)
- Dhivya Loganathan Sumathi
- Ahmed Alfarhan (ORCID: https://orcid.org/0000-0003-1998-2940)
- Bharath Kumar Chagaleti (ORCID: https://orcid.org/0000-0002-7835-8999)
- Venkatesan Saravanan (ORCID: https://orcid.org/0000-0003-3991-3600)
- Balasubramanian Haridevamuthu
- Ankit Kumar Bharti (ORCID: https://orcid.org/0009-0006-6219-4068)
- D. Narayanan
Institutions
- SRM Institute of Science and Technology (IN)
- Dr. M.G.R. Educational and Research Institute (IN)
- King Saud University (SA)
Publication Details
- Journal
- British Journal of Pharmacology
- Published
- 2024-12-22
- DOI
- https://doi.org/10.1111/bph.17426
- Citations
- 8
- Primary Topic
- Cholinesterase and Neurodegenerative Diseases
- Type
- article
- Field-Weighted Citation Impact
- 3.58
Funders
- King Saud University