Investigation into the Potential Mechanism of Radix Paeoniae Rubra Against Ischemic Stroke Based on Network Pharmacology
In conclusion, this study revealed that RPR alleviates ischemic injury by activating the MAPK signaling pathway, and its protective effect may partly stem from inhibiting platelet activation. This work may provide a scientific basis for the development and utilization of RPR as a natural edible material to prevent ischemic stroke and anti-platelet therapy.
Authors
- Xiuxian Yu
- Yueying Li (ORCID: https://orcid.org/0009-0005-3043-0225)
- Guang Xin (ORCID: https://orcid.org/0000-0002-1177-0671)
- Wen Huang (ORCID: https://orcid.org/0000-0002-9772-9492)
- Beiwei Zhu (ORCID: https://orcid.org/0000-0003-4674-2993)
- Kun Zhang (ORCID: https://orcid.org/0000-0003-3475-7127)
- Ting Liu (ORCID: https://orcid.org/0000-0003-1816-5551)
- Tao Wang (ORCID: https://orcid.org/0000-0002-8955-416X)
- Shiyi Li (ORCID: https://orcid.org/0000-0002-6635-8529)
- Ying Zhang (ORCID: https://orcid.org/0000-0002-5812-372X)
- Tingyu Wen
- Qilong Zhou (ORCID: https://orcid.org/0000-0001-9640-4445)
Institutions
- Sichuan University (CN)
- Dalian Polytechnic University (CN)
Publication Details
- Journal
- Nutrients
- Published
- 2024-12-23
- DOI
- https://doi.org/10.3390/nu16244409
- Citations
- 1
- Primary Topic
- Traditional Chinese Medicine Analysis
- Type
- article
- Field-Weighted Citation Impact
- 0.72
Funders
- Sichuan University
- Natural Science Foundation of Sichuan Province
- West China Hospital, Sichuan University