Longitudinal trajectories of digital upper limb biomarkers for multiple sclerosis
In this cohort of mild to moderate RRMS, MDT scores remained stable over time with no evidence of a practice effect at a population level. Trajectory analysis based on LCA identified a cohort with greater variability and risk of disability progression and domain specific worsening. Our findings demonstrate the importance of latent processes in determining upper limb function in pwMS.
Authors
- David Darby
- Jeannette Lechner‐Scott (ORCID: https://orcid.org/0000-0002-3850-447X)
- Daniel Merlo (ORCID: https://orcid.org/0000-0001-8766-3453)
- Yi Chao Foong (ORCID: https://orcid.org/0000-0001-6447-078X)
- Tomáš Kalinčík (ORCID: https://orcid.org/0000-0003-3778-1376)
- Katherine Buzzard (ORCID: https://orcid.org/0000-0003-4039-9303)
- Helmut Butzkueven (ORCID: https://orcid.org/0000-0003-3940-8727)
- Maria Pamela Dobay (ORCID: https://orcid.org/0000-0003-2611-0649)
- Steve Simpson (ORCID: https://orcid.org/0000-0001-6521-3056)
- Anneke van der Walt (ORCID: https://orcid.org/0000-0002-4278-7003)
- Melissa Gresle (ORCID: https://orcid.org/0000-0003-0738-1136)
- Robert Hyde (ORCID: https://orcid.org/0000-0002-8705-9405)
- Bruce Taylor (ORCID: https://orcid.org/0000-0003-2807-0070)
- Johan van Beek (ORCID: https://orcid.org/0000-0002-5641-0004)
- Trevor J. Kilpatrick (ORCID: https://orcid.org/0000-0003-3999-085X)
- Michael Harry Barnett (ORCID: https://orcid.org/0000-0002-2156-8864)
- Chao Zhu (ORCID: https://orcid.org/0000-0003-3951-7501)
Institutions
- The University of Sydney (AU)
- University of Tasmania (AU)
- The Royal Melbourne Hospital (AU)
- The University of Melbourne (AU)
- Florey Institute of Neuroscience and Mental Health (AU)
- Royal Hobart Hospital (AU)
- Cooperative Trials Group for Neuro-Oncology (AU)
- Eastern Health (AU)
- Biogen (Switzerland) (CH)
- Hunter New England Local Health District (AU)
- Melbourne Health (AU)
- Alfred Health (AU)
- Monash University (AU)
- University of Newcastle Australia (AU)
Publication Details
- Journal
- European Journal of Neurology
- Published
- 2024-12-23
- DOI
- https://doi.org/10.1111/ene.70000
- Citations
- 4
- Primary Topic
- Multiple Sclerosis Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.70
Funders
- Biogen
- Medical Research Council
- National Health and Medical Research Council