Response of the gut microbiome and metabolome to dietary fiber in healthy dogs
Consumption of dietary fiber changes the composition of the gut microbiome and, to a larger extent, the associated metabolites. Production of health-relevant metabolites such as short-chain fatty acids from fiber depends both on the consumption of a specific fiber and on the enrichment of beneficial metabolite-producing species in response to it. Even in a seemingly homogeneous population, the benefit received from fiber consumption is personalized and emphasizes specific fiber-microbe-host interactions. These observations are relevant for both population-wide and personalized nutrition applications.
Authors
- Curtis Huttenhower (ORCID: https://orcid.org/0000-0002-1110-0096)
- Aaron M. Walsh (ORCID: https://orcid.org/0000-0001-7058-728X)
- Matthew Irick Jackson (ORCID: https://orcid.org/0000-0001-7535-1831)
- Amrisha Bhosle (ORCID: https://orcid.org/0000-0001-8669-4979)
- Eric A. Franzosa (ORCID: https://orcid.org/0000-0002-8798-7068)
- Dayakar V. Badri (ORCID: https://orcid.org/0009-0007-1200-9597)
Institutions
- Broad Institute (US)
- Harvard University (US)
- Hill Top Research (United States) (US)
- Hill's Pet Nutrition (United States)
Publication Details
- Journal
- mSystems
- Published
- 2024-12-23
- DOI
- https://doi.org/10.1128/msystems.00452-24
- Citations
- 4
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- Harvard University
- Hill's Pet Nutrition
- FAS Division of Science, Harvard University