First-year dynamics of the anaerobic microbiome and archaeome in infants’ oral and gastrointestinal systems

The first year of life is a crucial period for establishing a healthy human microbiome. Our study analyses the role of archaea and obligate anaerobes in the development of the human oral and gut microbiome, with a specific focus on the impact of breastfeeding in this process. Our findings demonstrated that the oral and gut microbiomes of breastfed infants undergo distinct phases of increased dynamics within the first year of life. In contrast, the microbiomes of non-breastfed infants are more mature from the first month, leading to a steadier development without distinct transitional phases in the first year. Additionally, we found that archaeal signatures are present in infants under 1 year of age, but they do not form a stable archaeome. In contrast to this, we could track specific bacterial strains transitioning from oral to gut or persisting in the gut over time.

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Publication Details

Journal
mSystems
Published
2024-12-23
DOI
https://doi.org/10.1128/msystems.01071-24
Citations
2
Primary Topic
Gut microbiota and health
Type
article
Field-Weighted Citation Impact
0.47

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article

First-year dynamics of the anaerobic microbiome and archaeome in infants’ oral and gastrointestinal systems

Evelyn Jantscher‐Krenn, Alexander Mahnert, Charlotte Neumann, Christine Moissl‐Eichinger et al.
2 citations
mSystems
Gut microbiota and health
0.47
article

First-year dynamics of the anaerobic microbiome and archaeome in infants’ oral and gastrointestinal systems

Evelyn Jantscher‐Krenn, Alexander Mahnert, Charlotte Neumann, Christine Moissl‐Eichinger, Eva‐Christine Weiss, Rokhsareh Mohammadzadeh, Christina Kumpitsch, Pei Yee Woh, V Kolovetsiou-Kreiner, Manuela-Raluca Pausan, Victoria Haid, Tejus Shinde, Polona Mertelj, Tanja Kobal
article en
2 citations

Abstract

The first year of life is a crucial period for establishing a healthy human microbiome. Our study analyses the role of archaea and obligate anaerobes in the development of the human oral and gut microbiome, with a specific focus on the impact of breastfeeding in this process. Our findings demonstrated that the oral and gut microbiomes of breastfed infants undergo distinct phases of increased dynamics within the first year of life. In contrast, the microbiomes of non-breastfed infants are more mature from the first month, leading to a steadier development without distinct transitional phases in the first year. Additionally, we found that archaeal signatures are present in infants under 1 year of age, but they do not form a stable archaeome. In contrast to this, we could track specific bacterial strains transitioning from oral to gut or persisting in the gut over time.

mSystemsVol. 10(1)
Hong Kong Polytechnic University (HK), Medical University of Graz (AT), Biobanking and Biomolecular Resources Research Infrastructure Consortium (AT), Institute of Medical Microbiology and Hygiene (DE)
Austrian Science Fund, Universität Wien, Karl-Franzens-Universität Graz, Medizinische Universität Graz
Openalex Percentile: Top 33%
Gut microbiota and health
0.47
DOIOpen Access PDFOpenAlex
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