Multi-omics and experimental analysis unveil the key components in Scutellaria baicalensis Georgi to alleviate hepatic fibrosis via regulating cPLA2-mediated arachidonic acid metabolism
This study reveals that MESB is crucial in preventing hepatic fibrosis via the cPLA2-mediated arachidonic acid metabolic pathway, highlighting its key active components as potential drugs for fibrosis treatment.
Authors
- Honglin He
- Yi Liu (ORCID: https://orcid.org/0000-0003-0548-6073)
- Yuanyuan Liu (ORCID: https://orcid.org/0000-0001-6862-1928)
- Zhiwei Chen (ORCID: https://orcid.org/0000-0001-7951-3295)
- Zheng Pan (ORCID: https://orcid.org/0000-0002-9727-7975)
- Yi Yang (ORCID: https://orcid.org/0000-0001-6525-3920)
- Yujie Cheng
- Ailing Liang
Institutions
- Chongqing University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2024-12-23
- DOI
- https://doi.org/10.1186/s12967-024-05955-5
- Citations
- 14
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 5.41
Funders
- National Natural Science Foundation of China
- Chongqing Medical University
- Chongqing Municipal Education Commission
- Centre Scientifique et Technique du Bâtiment
- Natural Science Foundation Project of Chongqing, Chongqing Science and Technology Commission