The expression of pro-prion, a transmembrane isoform of the prion protein, leads to the constitutive activation of the canonical Wnt/β-catenin pathway to sustain the stem-like phenotype of human glioblastoma cells
The persistence of Pro-PrP in GSCs is an altered cellular mechanism responsible of the aberrant, constitutive activation of Wnt/β-catenin pathway, which contributes to glioblastoma malignant features. Thus, the activity of Pro-PrP may represent a targetable vulnerability in glioblastoma cells, offering a novel approach for differentiating and eradicating glioblastoma stem cells.
Authors
- Alessandro Corsaro (ORCID: https://orcid.org/0000-0003-4565-7914)
- Stefano Thellung (ORCID: https://orcid.org/0000-0002-2010-331X)
- Aldo Pagano (ORCID: https://orcid.org/0000-0001-8035-9299)
- Tullio Florio (ORCID: https://orcid.org/0000-0002-2394-996X)
- Irene Dellacasagrande (ORCID: https://orcid.org/0000-0003-1738-0444)
- Michele Tomanelli (ORCID: https://orcid.org/0000-0002-4010-0677)
- Federica Barbieri (ORCID: https://orcid.org/0000-0001-8988-6896)
Institutions
- Istituto Nazionale di Fisica Nucleare, Sezione di Genova (IT)
- Ospedale Policlinico San Martino (IT)
- University of Genoa (IT)
Publication Details
- Journal
- Cancer Cell International
- Published
- 2024-12-23
- DOI
- https://doi.org/10.1186/s12935-024-03581-1
- Citations
- 2
- Primary Topic
- Prion Diseases and Protein Misfolding
- Type
- article
- Field-Weighted Citation Impact
- 0.47