Novel approach to alleviate lupus nephritis: targeting the NLRP3 inflammasome in CD8+CD69+CD103+ TRM cells
NLRP3 inflammasome activity in renal CD8<sup>+</sup>CD69<sup>+</sup>CD103<sup>+</sup> T<sub>RM</sub> cells contributes to LN pathogenesis by regulating cell differentiation and effector functions. Therapeutically targeting the NLRP3 inflammasome could significantly mitigate CD8<sup>+</sup>CD69<sup>+</sup>CD103<sup>+</sup> T<sub>RM</sub> cell-mediated renal damage in LN.
Authors
- Chaohuan Guo (ORCID: https://orcid.org/0000-0002-1822-8017)
- Niansheng Yang (ORCID: https://orcid.org/0000-0003-2624-5658)
- Lili Zhuang (ORCID: https://orcid.org/0000-0002-5557-9959)
- Yimei Lai
- Jin Li (ORCID: https://orcid.org/0000-0001-9201-2321)
- Shuang Wang (ORCID: https://orcid.org/0000-0001-5933-074X)
- Mengyuan Li (ORCID: https://orcid.org/0000-0001-6856-6463)
- X. X. Zhu (ORCID: https://orcid.org/0000-0003-0828-299X)
- Jia Shi (ORCID: https://orcid.org/0000-0002-6912-6803)
- Binfeng Chen (ORCID: https://orcid.org/0000-0003-0868-7284)
- Mianjing Zhou
Institutions
- Sun Yat-sen University (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2024-12-23
- DOI
- https://doi.org/10.1186/s12967-024-05951-9
- Citations
- 8
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.87
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation