Data-driven CSF biomarker profiling: imaging and clinical outcomes in a cohort at risk of Alzheimer’s disease
Our results suggest that examining multiple CSF biomarkers reflecting diverse pathological pathways may complement and/or outperform AD core biomarkers and thresholding approaches to identify individuals showing a clinical and cognitive AD-like phenotype, including higher conversion to Aβ + , GM reductions and cognitive decline. The clinical utility of this approach warrants further investigation and replication in other cohorts.
Authors
- Müge Akinci (ORCID: https://orcid.org/0000-0002-0845-933X)
- Karine Fauria (ORCID: https://orcid.org/0000-0003-1506-4405)
- Nicholas James Ashton (ORCID: https://orcid.org/0000-0002-3579-8804)
- Ann Brinkmalm (ORCID: https://orcid.org/0000-0002-7396-3233)
- Gonzalo Sánchez‐Benavides (ORCID: https://orcid.org/0000-0003-3454-800X)
- Juan Lantero‐Rodriguez (ORCID: https://orcid.org/0000-0002-7426-678X)
- Marina García-Prat (ORCID: https://orcid.org/0000-0001-5387-1908)
- Eleni Palpatzis (ORCID: https://orcid.org/0000-0001-8478-273X)
- Eider M. Arenaza‐Urquijo (ORCID: https://orcid.org/0000-0001-7016-7576)
- Georgette Argiris (ORCID: https://orcid.org/0000-0003-0999-2926)
- Mahnaz Shekari (ORCID: https://orcid.org/0000-0003-1336-6768)
- Thomas K. Karikari (ORCID: https://orcid.org/0000-0003-1422-4358)
- Cleofé Peña-Gómez (ORCID: https://orcid.org/0009-0009-8043-8187)
- Oriol Grau‐Rivera (ORCID: https://orcid.org/0000-0002-4730-5341)
- Gwendlyn Kollmorgen
- Kaj Blennow
- Henrik Zetterberg (ORCID: https://orcid.org/0000-0003-3930-4354)
- Marc Suárez‐Calvet (ORCID: https://orcid.org/0000-0002-2993-569X)
- Clara Quijano‐Rubio (ORCID: https://orcid.org/0000-0001-9050-3282)
- for the ALFA study
Institutions
- Roche (Switzerland) (CH)
- University of Wisconsin–Madison (US)
- University of Pittsburgh (US)
- Universitat Pompeu Fabra (ES)
- King's College London (GB)
- Sahlgrenska University Hospital (SE)
- Instituto de Salud Carlos III (ES)
- Centre for Mental Health (GB)
- Roche Pharma AG (Germany) (DE)
- Pasqual Maragall Foundation (ES)
- Mayo Clinic in Arizona (US)
- UK Dementia Research Institute (GB)
- Barcelonaβeta Brain Research Center (ES)
- Hospital Del Mar (ES)
- Mayo Clinic in Florida (US)
- Barcelona Institute for Global Health (ES)
- Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (ES)
- University College London (GB)
- Columbia University (US)
- University of Gothenburg (SE)
Publication Details
- Journal
- Alzheimer s Research & Therapy
- Published
- 2024-12-23
- DOI
- https://doi.org/10.1186/s13195-024-01629-y
- Citations
- 8
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 3.08
Funders
- Alzheimer's Association
- Alzheimer's Drug Discovery Foundation
- Familjen Erling-Perssons Stiftelse
- Stiftelsen för Gamla Tjänarinnor
- EU Joint Programme – Neurodegenerative Disease Research
- National Institute for Health and Care Research
- University College London
- European Commission
- Hjärnfonden
- Vetenskapsrådet
- Ministerio de Ciencia e Innovación
- UK Dementia Research Institute
- Fundación Bancaria Caixa d'Estalvis i Pensions de Barcelona
- HORIZON EUROPE Framework Programme
- Instituto de Salud Carlos III
- European Social Fund