Piezo1 overexpression in the uterus contributes to myometrium contraction and inflammation-associated preterm birth
These results suggest that Piezo1 acts as a critical regulator of uterine function, and its overexpression may predispose to preterm labor through heightened myometrial activity and inflammation. The study underscores the potential of targeting Piezo1 as a therapeutic strategy to mitigate preterm birth associated with uterine inflammation.
Authors
- Yantong Wan
- Yunkai Tao
- Yongqiang Bi (ORCID: https://orcid.org/0000-0002-9183-657X)
- Xuemei Lin (ORCID: https://orcid.org/0000-0001-9267-0842)
- Qian Liu (ORCID: https://orcid.org/0000-0001-7415-0798)
- Hao Li (ORCID: https://orcid.org/0000-0001-5629-4261)
- Min Diao (ORCID: https://orcid.org/0009-0005-5899-6458)
- Lu Huang (ORCID: https://orcid.org/0009-0005-2530-569X)
Institutions
- Sichuan University (CN)
- West China Second University Hospital of Sichuan University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2024-12-23
- DOI
- https://doi.org/10.1186/s12967-024-05978-y
- Citations
- 6
- Primary Topic
- Erythrocyte Function and Pathophysiology
- Type
- article
- Field-Weighted Citation Impact
- 1.96
Funders
- National Natural Science Foundation of China