Identification of circulating risk biomarkers for cognitive decline in a large community‐based population in Chongqing China
From a large community-based cohort study on the residents in Chongqing, we have identified that mild cognitive impairment (MCI) and dementia share several common risk factors, including age, female gender, rural living, lower education levels, and a medical history of stroke. However, each condition also has its own unique risk factors. Several factors contribute to the progression of MCI into dementia including age, education levels, occupation, and a medical history of hypertension and epilepsy. We discover the correlations between the risk factors for dementia and blood biomarkers that indicate the presence of axonal damage, glial activation, and Aβ pathology.
Authors
- Qunying Li
- Jianzhong Duan
- Lingling Zheng (ORCID: https://orcid.org/0000-0002-7305-2253)
- Xiaolong Zeng (ORCID: https://orcid.org/0000-0003-4658-3515)
- Mengjiao Yu
- Junren Kang (ORCID: https://orcid.org/0000-0003-1011-6691)
- Weitao Zhou (ORCID: https://orcid.org/0009-0008-0427-7935)
- Xiaoling Duan (ORCID: https://orcid.org/0009-0006-0883-0369)
- Mingjing Liu
- Chenghui Liu (ORCID: https://orcid.org/0000-0001-8375-0242)
- Sipei Pan (ORCID: https://orcid.org/0000-0003-0811-0784)
- Chingwen Cheng (ORCID: https://orcid.org/0000-0002-9724-2190)
- Liangping Chen
- Xiaoqian Luan (ORCID: https://orcid.org/0000-0003-1395-4797)
- Chi Zhu (ORCID: https://orcid.org/0000-0003-4885-7305)
- Weihong Song (ORCID: https://orcid.org/0000-0001-9928-889X)
- Dandan Lou
- Xiaoyong Li (ORCID: https://orcid.org/0000-0001-8450-625X)
- Xin Wang (ORCID: https://orcid.org/0000-0001-9325-3194)
- Yun Liang Zhang (ORCID: https://orcid.org/0000-0002-5060-1213)
- Yong Zhang (ORCID: https://orcid.org/0000-0002-2692-5437)
- Yanhua Li (ORCID: https://orcid.org/0000-0003-0410-4686)
- Tingyu Li
- Yijun Feng (ORCID: https://orcid.org/0000-0002-7118-7509)
- Yuhang Liu (ORCID: https://orcid.org/0009-0006-6640-8473)
- Yu Kang (ORCID: https://orcid.org/0000-0002-8893-8698)
- Yong Yan (ORCID: https://orcid.org/0000-0002-1092-7892)
- Bo Deng (ORCID: https://orcid.org/0000-0002-5112-9221)
- Zhaohui Zhong (ORCID: https://orcid.org/0000-0002-8057-3065)
- Qian Zhang (ORCID: https://orcid.org/0000-0003-4580-171X)
- Yi-li Wu
- Zijuan Feng (ORCID: https://orcid.org/0009-0006-4140-9496)
- Shou Yang
- Huaqing Meng
- Huan Yang (ORCID: https://orcid.org/0000-0002-9053-5185)
- Xiu‐Qing Yao
- Chun‐Rong Liang
- Yin Zhong
- Sisi Ren (ORCID: https://orcid.org/0009-0008-3542-6868)
Institutions
- University of British Columbia (CA)
- Army Medical University (CN)
- Capital Medical University (CN)
- Wenzhou Medical University (CN)
- First Affiliated Hospital of Wenzhou Medical University (CN)
- Daping Hospital (CN)
- Nanjing Drum Tower Hospital (CN)
- Zhejiang Lab (CN)
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- BC Children's Hospital (CA)
- Chongqing Public Health Medical Center (CN)
- Children's Hospital of Chongqing Medical University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-23
- DOI
- https://doi.org/10.1002/alz.14443
- Citations
- 13
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 5.01
Funders
- National Natural Science Foundation of China
- China Scholarship Council
- Canadian Institutes of Health Research