Integrating rare pathogenic variant prioritization with gene‐based association analysis to identify novel genes and relevant multimodal traits for Alzheimer's disease
Identified 11 novel AD candidate genes in a Chinese AD cohort. Correlated candidate genes with AD-related cognitive and brain imaging traits. Indicated RABEP1 p.R845W as a critical AD contributor in the endocytic pathway.
Authors
- Zeji Zhang
- Jixin Cao (ORCID: https://orcid.org/0000-0001-6050-4276)
- Xing‐Ming Zhao (ORCID: https://orcid.org/0000-0002-4531-3970)
- Jing Ding (ORCID: https://orcid.org/0000-0002-0030-3816)
- Chun‐Yi Zac Lo (ORCID: https://orcid.org/0000-0003-3288-6259)
- Tian‐Lin Cheng (ORCID: https://orcid.org/0000-0003-0680-6710)
- Qihao Guo (ORCID: https://orcid.org/0000-0001-5079-8047)
- Feng Chen (ORCID: https://orcid.org/0000-0002-9054-943X)
- Jingqi Chen (ORCID: https://orcid.org/0000-0002-2454-0058)
- Cheng Zhang (ORCID: https://orcid.org/0000-0002-9218-5019)
- Xiaohui Luo
Institutions
- Shanghai Medical College of Fudan University (CN)
- Chung Yuan Christian University (TW)
- Shanghai Jiao Tong University (CN)
- Fudan University (CN)
- Shanghai Institute for Science of Science (CN)
- Zhongshan Hospital (CN)
- Hainan General Hospital (CN)
- Shanghai Sixth People's Hospital (CN)
- Children's Hospital of Fudan University (CN)
- Shanghai Center for Brain Science and Brain-Inspired Technology (CN)
- Hainan Medical University (CN)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-23
- DOI
- https://doi.org/10.1002/alz.14444
- Citations
- 8
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.61
Funders
- Natural Science Foundation of Shanghai
- Arizona Department of Health Services
- Northern California Institute for Research and Education
- National Key Laboratory of Human Factors Engineering
- National Natural Science Foundation of China
- Science and Technology Commission of Shanghai Municipality
- Arizona Biomedical Research Commission
- National Institutes of Health
- Canadian Institutes of Health Research
- National Key Research and Development Program of China
- National Institute on Aging
- National Institute of Biomedical Imaging and Bioengineering