Integrating rare pathogenic variant prioritization with gene‐based association analysis to identify novel genes and relevant multimodal traits for Alzheimer's disease

Identified 11 novel AD candidate genes in a Chinese AD cohort. Correlated candidate genes with AD-related cognitive and brain imaging traits. Indicated RABEP1 p.R845W as a critical AD contributor in the endocytic pathway.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2024-12-23
DOI
https://doi.org/10.1002/alz.14444
Citations
8
Primary Topic
Alzheimer's disease research and treatments
Type
article
Field-Weighted Citation Impact
2.61

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article

Integrating rare pathogenic variant prioritization with gene‐based association analysis to identify novel genes and relevant multimodal traits for Alzheimer's disease

Zeji Zhang, Jixin Cao, Xing‐Ming Zhao, Jing Ding et al.
8 citations
Alzheimer s & Dementia
Alzheimer's disease research and treatments
2.61
article

Integrating rare pathogenic variant prioritization with gene‐based association analysis to identify novel genes and relevant multimodal traits for Alzheimer's disease

Zeji Zhang, Jixin Cao, Xing‐Ming Zhao, Jing Ding, Chun‐Yi Zac Lo, Tian‐Lin Cheng, Qihao Guo, Feng Chen, Jingqi Chen, Cheng Zhang, Xiaohui Luo
article en
8 citations

Abstract

Identified 11 novel AD candidate genes in a Chinese AD cohort. Correlated candidate genes with AD-related cognitive and brain imaging traits. Indicated RABEP1 p.R845W as a critical AD contributor in the endocytic pathway.

Alzheimer s & DementiaVol. 21(2)
Shanghai Medical College of Fudan University (CN), Chung Yuan Christian University (TW), Shanghai Jiao Tong University (CN), Fudan University (CN), Shanghai Institute for Science of Science (CN), Zhongshan Hospital (CN), Hainan General Hospital (CN), Shanghai Sixth People's Hospital (CN), Children's Hospital of Fudan University (CN), Shanghai Center for Brain Science and Brain-Inspired Technology (CN), Hainan Medical University (CN)
Natural Science Foundation of Shanghai, Arizona Department of Health Services, Northern California Institute for Research and Education, National Key Laboratory of Human Factors Engineering, National Natural Science Foundation of China, Science and Technology Commission of Shanghai Municipality, Arizona Biomedical Research Commission, National Institutes of Health, Canadian Institutes of Health Research, National Key Research and Development Program of China, National Institute on Aging, National Institute of Biomedical Imaging and Bioengineering
Good health and well-being
Openalex Percentile: Top 9%
Alzheimer's disease research and treatments
2.61
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