Association of <i>APOE</i> alleles and polygenic profiles comprising <i>APOE</i> ‐ <i>TOMM40</i> ‐ <i>APOC1</i> variants with Alzheimer's disease neuroimaging markers
The ε4 allele is associated with smaller values of neuroimaging markers in AD cases. Larger values of neuroimaging markers may protect against AD in the ε4 carriers. TOMM40 and APOC1 variants differentiate AD risk in the ε4 carriers. The same variants can differentiate the links between ε4 and neuroimaging markers.
Authors
- Alexander M. Kulminski (ORCID: https://orcid.org/0000-0002-0205-8228)
- Heather Wilkins (ORCID: https://orcid.org/0000-0003-4563-4544)
- Alireza Nazarian (ORCID: https://orcid.org/0000-0001-5810-6834)
- Russell Howard Swerdlow (ORCID: https://orcid.org/0000-0003-2948-7230)
- Ethan Jain‐Washburn
- Robyn A. Honea (ORCID: https://orcid.org/0000-0002-4661-2024)
- Olivia J. Veatch (ORCID: https://orcid.org/0000-0002-5509-7749)
Institutions
- Social Science Research Council (US)
- University of Kansas (US)
- Duke University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-23
- DOI
- https://doi.org/10.1002/alz.14445
- Citations
- 6
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.96
Funders
- Duke University
- National Institute on Aging
- National Institute of General Medical Sciences
- National Center for Advancing Translational Sciences