A biocompatible Ni(<scp>ii</scp>) complex as an amyloid sensor for human PrP<sub>106–126</sub> fibrillar aggregates
KRS-1, a biocompatible nickel(II) complex, is introduced as a potent fluorescent probe for PrP<sub>106-126</sub> fibrillar aggregates. KRS-1 shows a 15-fold enhancement in PL intensity and detects all stages of PrP<sub>106-126</sub> aggregation. Fluorescence microscopy confirms its efficacy in identifying PrP<sub>106-126</sub> fibrillar aggregates in HT-22 cells.
Authors
- Govinda R. Navale (ORCID: https://orcid.org/0000-0002-3602-2346)
- Imtiaz Ahmed (ORCID: https://orcid.org/0000-0002-6736-1631)
- Abhishek Panwar (ORCID: https://orcid.org/0009-0006-3351-0447)
- Kaushik Ghosh (ORCID: https://orcid.org/0000-0002-3792-2848)
- Sain Singh (ORCID: https://orcid.org/0000-0001-6947-9388)
- Partha Roy (ORCID: https://orcid.org/0000-0003-1943-3079)
- Rajat Saini
- Saakshi Saini
- Prashant Kukreti
- Rahul Chauhan
Institutions
- Indian Institute of Technology Roorkee (IN)
- National Institute of Technology Manipur (IN)
Publication Details
- Journal
- Chemical Communications
- Published
- 2024-12-23
- DOI
- https://doi.org/10.1039/d4cc04335a
- Primary Topic
- Prion Diseases and Protein Misfolding
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Department of Science and Technology, Ministry of Science and Technology, India
- Council of Scientific and Industrial Research, India
- Ministry of Education, India