Stabilization of mitochondria‐associated endoplasmic reticulum membranes regulates Aβ generation in a three‐dimensional neural model of Alzheimer's disease
The stabilization of MAMs exacerbates or ameliorates Aβ generation from AD neurons in a MAM gap width-dependent manner. A specific stabilization threshold within the MAM gap width spectrum shifts the amyloidogenic process to non-amyloidogenic. Tight MAMs slow down mitochondrial axonal transport compared to lose MAMs offering a quantitative method for measuring MAM stabilization.
Authors
- Michelle M. Kim (ORCID: https://orcid.org/0000-0001-7566-6411)
- Selene Lomoio (ORCID: https://orcid.org/0000-0002-5151-295X)
- György Hajnóczky (ORCID: https://orcid.org/0000-0003-3813-2570)
- M Tarantino
- Raja Bhattacharyya (ORCID: https://orcid.org/0000-0002-9754-3380)
- Masato Maesako (ORCID: https://orcid.org/0000-0002-1970-2462)
- Jacob C. Zellmer
Institutions
- Tufts University (US)
- Harvard University (US)
- Thomas Jefferson University (US)
- Massachusetts General Hospital (US)
- MaineGeneral Medical Center (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-23
- DOI
- https://doi.org/10.1002/alz.14417
- Citations
- 10
- Primary Topic
- Mitochondrial Function and Pathology
- Type
- article
- Field-Weighted Citation Impact
- 2.34
Funders
- Massachusetts General Hospital
- Cure Alzheimer's Fund
- National Institutes of Health