Microglia internalize tau monomers and fibrils using distinct receptors but similar mechanisms
Microglial endocytosis of tau monomers and fibrils is dynamin-dependent. HSPG antagonism blocks microglial uptake of tau fibrils but not monomers. LRP1 antagonism or knockdown inconsistently inhibits tau uptake. TAT-Cre stimulates semi-selective uptake of fibrils over monomers.
Authors
- Jacob A. McPhail (ORCID: https://orcid.org/0000-0003-1490-808X)
- N. Sayre (ORCID: https://orcid.org/0000-0002-6124-2535)
- Jessica L. Wickline (ORCID: https://orcid.org/0000-0002-0722-933X)
- Sarah C. Hopp (ORCID: https://orcid.org/0000-0001-5228-0022)
- Ariel Louwrier (ORCID: https://orcid.org/0000-0003-1472-5494)
- Eduardo Gutierrez Kuri (ORCID: https://orcid.org/0009-0001-8405-6612)
- Sabrina Smith
- Kristian F. Falkon (ORCID: https://orcid.org/0000-0003-4152-4583)
- Liliana Danford
- Paulina Esquinca‐Moreno
- Yaren L. Peña Señeriz (ORCID: https://orcid.org/0000-0001-6593-7628)
Institutions
- The University of Texas at San Antonio Health Science Center (US)
- University of California, San Francisco (US)
- South Texas Veterans Health Care System (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-23
- DOI
- https://doi.org/10.1002/alz.14418
- Citations
- 16
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 5.22
Funders
- Alzheimer's Association
- Cancer Prevention and Research Institute of Texas
- Max and Minnie Tomerlin Voelcker Fund
- National Institutes of Health
- National Cancer Institute