Co‐pathologies modify hippocampal protein accumulation patterns in neurodegenerative diseases
Alzheimer's disease-related phosphorylated tau predominates in the prosubiculum. Amyloid beta predominates in the CA1 and Lewy body-related α-synuclein in the CA2. The area density of protein deposition increases with the disease stage up to a peak. In the high pathology stage, protein deposition and pyramidal cell density decreases. Comorbid protein pathology affects the pattern of protein accumulation.
Authors
- Hidetomo Tanaka
- Gábor G. Kovács
- Tomoya Kon (ORCID: https://orcid.org/0000-0001-6072-3954)
- Kōji Yoshida (ORCID: https://orcid.org/0000-0003-1841-8117)
- Shelley L. Forrest
- Shojiro Ichimata (ORCID: https://orcid.org/0000-0002-7305-8137)
Institutions
- University Health Network (CA)
- Hirosaki University (JP)
- University of Toronto (CA)
- Discovery Centre (CA)
- Ontario Brain Institute (CA)
- University of Toyama (JP)
- Macquarie University (AU)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-23
- DOI
- https://doi.org/10.1002/alz.14355
- Citations
- 7
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.29
Funders
- Edmond J. Safra Philanthropic Foundation