Differences in baseline cognitive performance between participants with early‐onset and late‐onset Alzheimer's disease: Comparison of LEADS and ADNI
Both early-onset Alzheimer's disease (EOAD) and late-onset Alzheimer's disease (LOAD) participants displayed widespread cognitive impairments relative to their same-aged peers. Cognitive impairments were more severe for EOAD than for LOAD participants in visuospatial and executive domains. Memory and language impairments were more severe for LOAD than for EOAD participants Results were comparable after removing clinical phenotypes of posterior cortical atrophy (PCA), primary progressive aphasia (lv-PPA), and frontal-variant AD.
Authors
- Lawrence S. Honig (ORCID: https://orcid.org/0000-0002-9703-2265)
- Alireza Atri (ORCID: https://orcid.org/0000-0003-4405-6973)
- Angelina J. Polsinelli (ORCID: https://orcid.org/0000-0002-7738-9574)
- Renaud La Joie (ORCID: https://orcid.org/0000-0003-2581-8100)
- Julien Lagarde (ORCID: https://orcid.org/0000-0002-2018-261X)
- Alexander Taurone
- María C. Carrillo (ORCID: https://orcid.org/0000-0003-3057-2387)
- Joseph C. Masdeu (ORCID: https://orcid.org/0000-0001-9955-6954)
- Erik S. Musiek (ORCID: https://orcid.org/0000-0002-8873-0360)
- Ian Grant (ORCID: https://orcid.org/0000-0001-6960-6762)
- Liana G. Apostolova (ORCID: https://orcid.org/0000-0003-1823-2451)
- Paul S. S Aisen (ORCID: https://orcid.org/0000-0002-2896-5838)
- Sujuan Gao (ORCID: https://orcid.org/0000-0002-6741-6380)
- David A. Wolk (ORCID: https://orcid.org/0000-0002-3554-3481)
- Erik C. B. Johnson (ORCID: https://orcid.org/0000-0002-0604-2944)
- Jeffrey L. Dage (ORCID: https://orcid.org/0000-0002-2192-1699)
- Chiadi U. Onyike (ORCID: https://orcid.org/0000-0003-2255-4437)
- Gil Dan Rabinovici (ORCID: https://orcid.org/0000-0002-3626-4265)
- Dustin B. Hammers (ORCID: https://orcid.org/0000-0002-1644-2618)
- Kyle Womack (ORCID: https://orcid.org/0000-0002-6060-9075)
- Laurel Beckett (ORCID: https://orcid.org/0000-0002-2418-9843)
- Sharon J. Sha (ORCID: https://orcid.org/0000-0002-3666-1463)
- Emily Rogalskı (ORCID: https://orcid.org/0000-0002-6472-1363)
- Gregory Scott Day (ORCID: https://orcid.org/0000-0001-5133-5538)
- David Thomas Jones (ORCID: https://orcid.org/0000-0002-4807-9833)
- Kelly Nudelman (ORCID: https://orcid.org/0000-0003-4040-1717)
- David A. Clark (ORCID: https://orcid.org/0000-0002-8334-492X)
- Mario F. Mendez (ORCID: https://orcid.org/0000-0001-6441-7989)
- Ani Eloyan (ORCID: https://orcid.org/0000-0002-8110-7680)
- Ranjan Duara (ORCID: https://orcid.org/0000-0001-8060-6309)
- Bradford Clark Dickerson (ORCID: https://orcid.org/0000-0002-5958-3445)
- Raymond Scott Turner (ORCID: https://orcid.org/0000-0001-7534-2935)
- Neill R. Graff‐Radford (ORCID: https://orcid.org/0000-0001-9847-9096)
- Thomas S. Wingo (ORCID: https://orcid.org/0000-0002-7679-6282)
- Kala Kirby
- Steven Salloway
- Maryanne Thangarajah
- Meghan Riddle
- Rema Reman
Institutions
- Northwestern University (US)
- University of Southern California (US)
- Alzheimer's Association (US)
- Autism Research Institute (US)
- Houston Methodist (US)
- Mayo Clinic (US)
- Harvard University (US)
- Johns Hopkins University (US)
- Emory University (US)
- University of California, Los Angeles (US)
- University of California, San Francisco (US)
- Georgetown University (US)
- Washington University in St. Louis (US)
- Cornell University (US)
- Brown University (US)
- Columbia University Irving Medical Center (US)
- Johns Hopkins Medicine (US)
- Jacksonville College (US)
- University of Chicago (US)
- Massachusetts General Hospital (US)
- Mount Sinai Medical Center (US)
- Methodist Hospital (US)
- Banner Sun Health Research Institute (US)
- Mayo Clinic in Florida (US)
- Weill Cornell Medicine (US)
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
- University of Pennsylvania (US)
- University of California, Davis (US)
- Stanford University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-23
- DOI
- https://doi.org/10.1002/alz.14218
- Citations
- 13
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 5.01
Funders
- U.S. Department of Defense
- Alzheimer's Association
- Bristol-Myers Squibb
- Alzheimer's Drug Discovery Foundation
- Eli Lilly and Company
- Pfizer
- Merck
- Roche
- Biogen
- AbbVie
- Alzheimer's Disease Neuroimaging Initiative
- BioClinica
- Novartis Pharmaceuticals Corporation
- Takeda Pharmaceutical Company
- Eisai
- Fujirebio Europe
- Servier
- H. Lundbeck A/S
- Fondation pour la Recherche sur Alzheimer
- National Institutes of Health
- Genentech
- GE Healthcare
- University of California, San Francisco
- National Institute on Aging
- National Institute of Biomedical Imaging and Bioengineering