SQLE-mediated squalene metabolism promotes tumor immune evasion in pancreatic cancer
Our study shows that squalene is an important immune-modulating metabolite that inhibits the infiltration of immune-suppressive cells in TIME, and that SQLE exerts its tumor immune evasion effect by metabolic removal of squalene. Thus, SQLE-mediated squalene metabolic pathway could be a potential target to enhance antitumor immunity in pancreatic cancer.
Authors
- Bitao Huo
- Haixi Liang (ORCID: https://orcid.org/0000-0002-7391-0270)
- Junchen Pan (ORCID: https://orcid.org/0009-0005-6614-5290)
- Rui Liu
- Peng Huang (ORCID: https://orcid.org/0000-0002-2152-9152)
- Lin Zhou (ORCID: https://orcid.org/0009-0001-9740-1980)
- Wenhua Lu
Institutions
- Sun Yat-sen University (CN)
- Sun Yat-sen University Cancer Center (CN)
- State Key Laboratory of Oncology in South China
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-12-23
- DOI
- https://doi.org/10.3389/fimmu.2024.1512981
- Citations
- 3
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.86