CHARACTERISTICS OF ULTRASTRUCTURE AND PROSTATE MICROCIRCULATORY BED IN BENIGN PROSTATIC HYPERPLASIA IN MEN WITH DIFFERENT BODY WEIGHT

Benign prostatic hyperplasia (BPH) is a common disease among older men. The main factors leading to its development are hormonal, age-related, alimentary and metabolic ones, including excess body weight and obesity. Objective. The aim of the study is to evaluate the severity of clinical symptoms, the area of the microcirculatory bed (MCB) and ultrastructural characteristics of the prostate gland in BPH men with different body weight. Materials and Methods. Patients (n=131) with BPH were divided into 3 groups according to body mass index: group 1 – normal body weight (n=38); group 2 – overweight (n=55); group 3 – class 1 obesity (n=38). One hundred patients were surveyed with IPSS and QoL questionnaires. In some men, a fragment of the surgical prostate capsule was collected intraoperatively. Histological material for light and electron microscopy, and for immunohistochemical detection of CD31 was prepared in a standard way. Results. Patients of groups 2 and 3 report lower quality of life (QoL) and more pronounced lower urinary tract symptoms (LUTS). In these men, the proportion of connective tissue around adenomeres of the prostate glands increases by 18.5 and 19 %, respectively. The relative area of microvascular vessels in overweight decreases by more than 2 times, and in Class 1 obesity – by 4 times. Electron microscopy revealed an increased number of collagen fibers around microvascular vessels. Conclusion. Increased body weight aggravates BPH clinical progression due to increased LUTS severity, decreases the area of microvascular vessels and increases the proportion of connective tissue in the prostate components.