Two-step continuous flow-driven synthesis of 1,1-cyclopropane aminoketones
The continuous flow telescoped synthesis of 1,1-cyclopropane aminoketones was achieved by optimizing the photocyclization of 1,2-diketones to 2-hydroxycylobutanones (HCBs) and their reaction with aryl- and alkylamines, <i>via</i> tandem condensation C4-C3-ring contraction reaction. With the achieved operational conditions, we were able to obtain a library of cyclopropylamines with good chemical yields, high productivity, and short residence times.
Authors
- Roberto Scipione (ORCID: https://orcid.org/0009-0001-5978-8870)
- Dario Cambié (ORCID: https://orcid.org/0000-0003-2722-5106)
- Maria Chiara Cabua (ORCID: https://orcid.org/0000-0002-3151-9302)
- Alberto Luridiana (ORCID: https://orcid.org/0000-0002-7828-9866)
- Francesco Soddu (ORCID: https://orcid.org/0000-0003-1816-7389)
- Davide Moi (ORCID: https://orcid.org/0000-0002-2470-9351)
- Francesco Secci (ORCID: https://orcid.org/0000-0003-0443-2890)
- Enrico Podda (ORCID: https://orcid.org/0000-0002-4329-7751)
- Viktoria Velichko (ORCID: https://orcid.org/0009-0008-5949-8428)
Institutions
- University of Cagliari (IT)
- Max Planck Institute of Colloids and Interfaces (DE)
Publication Details
- Journal
- Chemical Communications
- Published
- 2024-12-23
- DOI
- https://doi.org/10.1039/d4cc04089a
- Citations
- 2
- Primary Topic
- Cyclopropane Reaction Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.50
Funders
- Deutscher Akademischer Austauschdienst