Lewy body co‐pathology in Alzheimer's disease and primary age‐related tauopathy contributes to differential neuropathological, cognitive, and brain atrophy patterns
Lewy body (LB) co-pathology is frequent in Alzheimer's disease (AD) with important clinical implications. LB co-pathology is also present in primary age-related tauopathy (PART), but its significance is still understudied. In PART and AD, LB leads to higher cognitive impairment and brain regional atrophy. In PART and AD, LB tends to accompany neurofibrillary tangle progression, suggesting amyloid pathology might be a trigger for regional pathology progression.
Authors
- Tiago Gil Oliveira (ORCID: https://orcid.org/0000-0003-0509-0562)
- Kathryn Gauthreaux
- Ana Coelho (ORCID: https://orcid.org/0000-0001-8489-5750)
- Miguel Quintas‐Neves
- Walter A. Kukull (ORCID: https://orcid.org/0000-0001-8761-9014)
- Charles Mock (ORCID: https://orcid.org/0000-0002-0564-568X)
- Tiago Jesus (ORCID: https://orcid.org/0000-0003-1437-5439)
- John F. Crary (ORCID: https://orcid.org/0000-0002-0556-293X)
- Francisco Almeida (ORCID: https://orcid.org/0000-0002-8404-4136)
- Alexandra Santos (ORCID: https://orcid.org/0000-0002-7381-043X)
Institutions
- Allen Institute for Brain Science (US)
- University of Washington (US)
- Hospital Braga (PT)
- Centro Hospitalar do Porto (PT)
- Icahn School of Medicine at Mount Sinai (US)
- University of Minho (PT)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-22
- DOI
- https://doi.org/10.1002/alz.14191
- Citations
- 13
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 5.01
Funders
- Fundação Amélia de Mello
- Foundation for Science and Technology
- National Institutes of Health
- Tau Consortium
- National Institute on Aging