Photoredox Catalytic Defluoroalkylation of <i>gem</i>-Difluoroalkenes with Secondary <i>N</i>-Alkylanilines via C–F/C–H Coupling
To provide fluorinated allylamines, a visible-light photocatalytic C-F/C-H coupling of easily accessible <i>gem</i>-difluoroalkenes and secondary <i>N</i>-alkylanilines was described. The protocol proceeded under mild conditions, with excellent functional group compatibility and a broad scope including complex natural product derivatives, thus providing a green method for the preparation of high-value functionalized monofluoroalkenes. Mechanistic studies elucidated a photoredox catalyzed radical-radical coupling pathway.
Authors
- Wengang Xu (ORCID: https://orcid.org/0000-0002-8468-8468)
- Congjian Xia
- Yifan Liu (ORCID: https://orcid.org/0000-0002-1785-4614)
- Hai Hu (ORCID: https://orcid.org/0000-0002-5348-5641)
- Mingbo Wu (ORCID: https://orcid.org/0000-0003-0048-778X)
- Guoqiang Xu (ORCID: https://orcid.org/0000-0002-0465-7152)
- Baokai Yang
Institutions
- Qingdao Institute of Bioenergy and Bioprocess Technology (CN)
- China University of Petroleum, East China (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2024-12-23
- DOI
- https://doi.org/10.1021/acs.orglett.4c04432
- Citations
- 2
- Primary Topic
- Fluorine in Organic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.42
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Natural Science Foundation of Shandong Province
- Major Scientific and Technological Innovation Project of Shandong Province