Biochemical Changes and Plasma Level of Lipoprotein-Associated Phospholipase A2 in Patients with and without Coronary Artery Disease: A Cross-Sectional Study

Coronary artery disease (CAD) is the leading cause of death worldwide. the aim of study is to evaluate the association between plasma lipoprotein-associated phospholipase A2 (Lp-PLA2) and the clinical and biochemical risk factors for CAD among Libyan individuals. This cross-sectional study to evaluate plasma concentration of Lp-PLA2 between patients with CAD and those without CAD in both genders based on clinical history, exercise ECG, two-dimensional echocardiography, and coronary angiography. Several biochemical parameters were estimated. Plasma levels of Lp-PLA2 were measured. A total of 181 individuals were recruited for this study, involving 125 with CAD and 56 without CAD. Plasma Lp-PLA2 concentration was significantly higher in patients with CAD versus individuals without coronary artery disease. In addition, the plasma concentration of Lp-PLA2 was higher in patients >60 years of age compared with patients <60 years old. To conclude that Plasma level of Lp-PLA2 concentration was independently correlated with CAD, inflammatory marker such as high sensitivity C-reactive protein among Libyan patients.