Suzuki–Miyaura/Mizoroki–Heck coupling cascade to access 2,2′-bifunctionalized biaryls
Biaryl motifs are essential structural features in several drugs and functional molecules. Cyclic diaryliodonium has been scarcely explored as a bifunctional agent compared to ring opening and annulation reactions. Herein, a three-component cascade approach is developed to synthesize bifunctionalized biaryls employing cyclic diaryliodoniums as a biarylating agent. The mild conditions enabled a vast array of biarylated products in good yields in a single step. Furthermore, preliminary mechanistic details and photophysical properties have been investigated.
Authors
- Ruchir Kant
- Naveen Kumar Maurya (ORCID: https://orcid.org/0000-0001-8006-3316)
- Asit Kumar (ORCID: https://orcid.org/0000-0003-1735-7033)
- Malleswara Rao Kuram (ORCID: https://orcid.org/0000-0003-0711-1275)
- Ankita Sahu
- Vishal Govind Rao (ORCID: https://orcid.org/0000-0003-1205-3006)
- Ajeet Kumar Singh (ORCID: https://orcid.org/0000-0002-2292-2116)
- Sanjeev K. Shukla
Institutions
- Central Drug Research Institute (IN)
- Indian Institute of Technology Kanpur (IN)
- Academy of Scientific and Innovative Research (IN)
Publication Details
- Journal
- Chemical Communications
- Published
- 2024-12-23
- DOI
- https://doi.org/10.1039/d4cc05763e
- Citations
- 3
- Primary Topic
- Chemical synthesis and alkaloids
- Type
- article
- Field-Weighted Citation Impact
- 0.75
Funders
- Science and Engineering Research Board