Influence of CYP2C8*3 and ABCG2 C421A genetic polymorphisms on trough concentration and molecular response of imatinib in Egyptian patients with chronic myeloid leukemia
The ABCG2 C421A polymorphism significantly influenced imatinib plasma trough concentrations and molecular responses in Egyptian chronic-phase CML patients. Genotyping of this polymorphism in these patients could assist in optimizing imatinib therapy, predicting more favorable treatment outcomes, and enabling the development of more personalized treatment plans.
Authors
- Mohammed S. Molla (ORCID: https://orcid.org/0000-0002-5990-6152)
- A Hussein (ORCID: https://orcid.org/0000-0002-0408-4366)
- Hanan A. Eltyb
- Mahmoud H. Abdel-Raheem
- Safwat A. Mangoura
Institutions
- Badr University in Cairo (EG)
- Assiut University (EG)
Publication Details
- Journal
- Cancer Chemotherapy and Pharmacology
- Published
- 2024-12-23
- DOI
- https://doi.org/10.1007/s00280-024-04723-y
- Citations
- 3
- Primary Topic
- Chronic Myeloid Leukemia Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.36
Funders
- Assiut University