Downregulation of the MARC1 p.A165 risk allele reduces hepatocyte lipid content by increasing beta-oxidation
MARC1 downregulation in carriers of the risk allele results in lower hepatocyte neutral lipids content due to higher β-oxidation, while upregulating beneficial pathways involved in cell survival.
Authors
- Marcus Henricsson (ORCID: https://orcid.org/0000-0002-4202-0339)
- Oveis Jamialahmadi (ORCID: https://orcid.org/0000-0001-7139-4738)
- Patrizio Candeloro (ORCID: https://orcid.org/0000-0001-6156-887X)
- Stefano Romeo (ORCID: https://orcid.org/0000-0001-9168-4898)
- Daniel Lindén (ORCID: https://orcid.org/0000-0003-4158-8018)
- Angela Mirarchi (ORCID: https://orcid.org/0000-0002-5006-9933)
- Kavitha Sasidharan (ORCID: https://orcid.org/0000-0003-3706-4692)
- Lohitesh Kovooru
- Ester Ciociola (ORCID: https://orcid.org/0000-0003-1186-5563)
- Salvatore Petta (ORCID: https://orcid.org/0000-0002-0822-9673)
- Luca Tirinato (ORCID: https://orcid.org/0000-0001-9826-2129)
- Samantha Maurotti (ORCID: https://orcid.org/0000-0001-7644-1337)
- Bernardette Scopacasa
- Arturo Pujia (ORCID: https://orcid.org/0000-0003-0763-4930)
- Grazia Pennisi (ORCID: https://orcid.org/0000-0001-9518-4751)
- Francesca Rita Noto (ORCID: https://orcid.org/0009-0007-9293-1433)
- Rosellina Margherita Mancina (ORCID: https://orcid.org/0000-0002-1126-3071)
- Tanmoy Dutta (ORCID: https://orcid.org/0000-0003-2816-2899)
Institutions
- Università Campus Bio-Medico (IT)
- Sahlgrenska University Hospital (SE)
- Karolinska Institutet (SE)
- Magna Graecia University (IT)
- AstraZeneca (Sweden) (SE)
- PromoFirenze (IT)
- Link Campus University (IT)
- University of Gothenburg (SE)
- University of Palermo (IT)
Publication Details
- Journal
- Clinical and Molecular Hepatology
- Published
- 2024-12-23
- DOI
- https://doi.org/10.3350/cmh.2024.0642
- Citations
- 11
- Primary Topic
- Folate and B Vitamins Research
- Type
- article
- Field-Weighted Citation Impact
- 5.17
Funders
- Science for Life Laboratory
- Sahlgrenska Akademin