Association between somatic microsatellite instability, hypermutation status, and specific T cell subsets in colorectal cancer tumors
This study helps us better understand how a clinically relevant tumor phenotype, microsatellite instability status, is related to different functioning T cell densities in colorectal tumors, which may impact future immunotherapy strategies.
Authors
- Amanda I. Phipps (ORCID: https://orcid.org/0000-0002-1446-2201)
- Yasutoshi Takashima (ORCID: https://orcid.org/0009-0009-0430-454X)
- Claire Elizabeth Thomas (ORCID: https://orcid.org/0000-0001-9515-3277)
- Steven Gallinger (ORCID: https://orcid.org/0000-0001-5004-8393)
- Jeroen R. Huyghe (ORCID: https://orcid.org/0000-0001-6027-9806)
- Ulrike Peters (ORCID: https://orcid.org/0000-0001-5666-9318)
- Robert S. Steinfelder (ORCID: https://orcid.org/0000-0003-4204-8013)
- Sushma Thomas
- Jonathan Andrew Nowak (ORCID: https://orcid.org/0000-0002-0943-7407)
- Li Hsu (ORCID: https://orcid.org/0000-0002-1604-3043)
- Daniel D. Buchanan (ORCID: https://orcid.org/0000-0003-2225-6675)
- Evertine Wesselink (ORCID: https://orcid.org/0000-0001-9347-7913)
- Andressa Dias Costa (ORCID: https://orcid.org/0000-0003-1046-4899)
- Shuji Ogino (ORCID: https://orcid.org/0000-0002-3909-2323)
- Tomotaka Ugai
- Robert C. Grant (ORCID: https://orcid.org/0000-0002-9821-0377)
- Conghui Qu (ORCID: https://orcid.org/0000-0003-1927-6245)
Institutions
- Broad Institute (US)
- Brigham and Women's Hospital (US)
- The Royal Melbourne Hospital (AU)
- University Health Network (CA)
- Harvard University (US)
- The University of Melbourne (AU)
- University of Washington (US)
- Lunenfeld-Tanenbaum Research Institute (CA)
- Princess Margaret Cancer Centre (CA)
- Fred Hutch Cancer Center (US)
- Dana-Farber Cancer Institute (US)
- Sinai Health System (CA)
- Dana-Farber/Harvard Cancer Center (US)
- Institute of Science Tokyo (JP)
- Massachusetts Institute of Technology (US)
- Wageningen University & Research (NL)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-12-23
- DOI
- https://doi.org/10.3389/fimmu.2024.1505896
- Citations
- 7
- Primary Topic
- Genetic factors in colorectal cancer
- Type
- article
- Field-Weighted Citation Impact
- 2.97
Funders
- Prevent Cancer Foundation
- Brigham and Women's Hospital
- Fred Hutchinson Cancer Research Center
- Harvard T.H. Chan School of Public Health
- Cancer Research UK
- National Institutes of Health
- Centers for Disease Control and Prevention
- Canadian Institutes of Health Research
- Medical Research Council
- National Health and Medical Research Council
- Ontario Ministry of Research and Innovation
- National Cancer Institute
- Office of Research Infrastructure Programs, National Institutes of Health