A supercritical oil extract of Schisandra chinensis seeds ameliorates Huntington’s disease-like symptoms and neuropathology: the potential role of anti-oxidant and anti-inflammatory effects
SOSC might ameliorate movement dysfunction by inhibiting neuropathology through its anti-inflammatory and antioxidant activities in the striata of 3-NPA-intoxicated mice. These findings suggest that SOSC could serve as a promising therapeutic candidate for HD-like symptoms, providing a foundation for future treatment strategies targeting neuroinflammation and oxidative stress.
Authors
- So-Ri Son (ORCID: https://orcid.org/0000-0002-7139-6394)
- Yujeong Ha (ORCID: https://orcid.org/0000-0002-9109-2240)
- Sang‐Kwan Moon (ORCID: https://orcid.org/0000-0003-0497-3080)
- Dae Sik Jang (ORCID: https://orcid.org/0000-0001-5472-5232)
- Tae Woo Kwon (ORCID: https://orcid.org/0000-0003-2417-9458)
- Ik‐Hyun Cho (ORCID: https://orcid.org/0000-0002-1036-0494)
- Youn-Woo Lee (ORCID: https://orcid.org/0000-0003-4793-6693)
- Min Soo Kim (ORCID: https://orcid.org/0000-0003-1892-8061)
- Hyo-Sung Jo
Institutions
- Seoul National University (KR)
- Kyung Hee University (KR)
- Korea Institute of Brain Science (KR)
- Kyung Hee University Medical Center (KR)
- Korean Association Of Science and Technology Studies (KR)
- Korea Institute of Science and Technology (KR)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2024-12-23
- DOI
- https://doi.org/10.3389/fphar.2024.1471024
- Citations
- 1
- Primary Topic
- Genetic Neurodegenerative Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.27
Funders
- National Research Foundation
- National Research Foundation of Korea