WhiA transcription factor provides feedback loop between translation and energy production in a genome-reduced bacterium
We propose the following model for <i>M. gallisepticum</i> WhiA function. WhiA remains bound to the core motif at any conditions. At low ATP concentrations (starvation) HEN domain binds auxiliary motif and represses <i>rpsJ</i> operon transcription. At high ATP concentrations (nutrient-rich conditions) HEN domain binds ATP and releases auxiliary motif. It leads to the de-repression of <i>rpsJ</i> operon and increased production of ribosomal proteins.
Authors
- Gleb Y. Fisunov (ORCID: https://orcid.org/0000-0002-6302-8305)
- Anna M. Varizhuk (ORCID: https://orcid.org/0000-0001-9359-8651)
- Daria V. Evsyutina (ORCID: https://orcid.org/0000-0001-8428-5362)
- Sergey I. Kovalchuk (ORCID: https://orcid.org/0000-0001-5273-3431)
- Irina Garanina (ORCID: https://orcid.org/0000-0003-1135-6558)
- Nicolay A. Barinov
- Vadim Markovich Govorun (ORCID: https://orcid.org/0000-0003-0837-8764)
- Alexey Vedyaykin (ORCID: https://orcid.org/0000-0002-4249-9837)
- Tatiana A. Semashko (ORCID: https://orcid.org/0000-0001-5389-2776)
- Vladimir B. Tsvetkov (ORCID: https://orcid.org/0000-0003-0494-3332)
- Valentin A. Manuvera (ORCID: https://orcid.org/0000-0002-2471-0563)
- Olga V. Pobeguts (ORCID: https://orcid.org/0000-0001-5265-7627)
- E. A. Tsoy (ORCID: https://orcid.org/0000-0003-0021-3957)
- Alexander I. Zubov
Institutions
- Russian Academy of Sciences (RU)
- Sechenov University (RU)
- Peter the Great St. Petersburg Polytechnic University (RU)
- InSysBio (Russia) (RU)
- Institute of Bioorganic Chemistry (RU)
- A.V. Topchiev Institute of Petrochemical Synthesis (RU)
- Federal Medical-Biological Agency (RU)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2024-12-23
- DOI
- https://doi.org/10.3389/fmicb.2024.1504418
- Citations
- 2
- Primary Topic
- RNA and protein synthesis mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.47