Detection of aberrant locomotor activity in a mouse model of lung cancer via home cage monitoring
Transgenic animal models represent a fundamental tool to study the biology of cancers and the development of new therapies. The tumors induced in these models harbor the same genotypical and phenotypical characteristics as their human counterparts. DVC methods permit a home cage monitoring system useful for tracking animal behavior continuously 24 hours a day, 7 days a week. DVC system could determine disease progression by monitoring a single animal activity in a cage and also using group-housed animals. For these reasons, the DVC system could play a crucial role in identifying diseases at early stages and in testing new therapeutic approaches with a higher likelihood of efficacy.
Authors
- Federica Guffanti (ORCID: https://orcid.org/0000-0001-7723-9974)
- Mirko Marabese (ORCID: https://orcid.org/0000-0001-9379-0301)
- Giulia Vargiu (ORCID: https://orcid.org/0009-0000-7941-8650)
- Mara Rigamonti (ORCID: https://orcid.org/0000-0002-3913-4458)
- Elisa Caiola (ORCID: https://orcid.org/0000-0002-9624-5533)
- Michele Tomanelli (ORCID: https://orcid.org/0000-0002-4010-0677)
- Edoardo Micotti (ORCID: https://orcid.org/0000-0002-5995-2992)
- Massimo Broggini (ORCID: https://orcid.org/0000-0002-8138-9358)
- Francesca Tumiatti
Institutions
- Mario Negri Institute for Pharmacological Research (IT)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2024-12-23
- DOI
- https://doi.org/10.3389/fonc.2024.1504938
- Citations
- 2
- Primary Topic
- Cancer Cells and Metastasis
- Type
- article
- Field-Weighted Citation Impact
- 0.57
Funders
- Associazione Italiana per la Ricerca sul Cancro