HLA-E/Mtb specific CD4+ and CD8+ T cells have a memory phenotype in individuals with TB infection
We show that HIV co-infection is the main driver in changing the memory distribution of HLA-E/<i>Mtb</i> specific CD4<sup>+</sup> and CD8<sup>+</sup> T cell subsets. HLA-E/<i>Mtb</i> specific CD4<sup>+</sup> and CD8<sup>+</sup> T cells were found to circulate with comparable frequencies in all individuals and displayed expression of KLRG1, PD-1 and 2B4 similar to that of total T cells. The presence of HLA-E/<i>Mtb</i> specific T cells in individuals with aTB and TBI highlights the potential of HLA-E as a vaccine target for TB.
Authors
- Tom H. M. Ottenhoff (ORCID: https://orcid.org/0000-0003-3706-3403)
- Kees L. M. C. Franken (ORCID: https://orcid.org/0000-0002-4747-6060)
- Marjolein van Wolfswinkel (ORCID: https://orcid.org/0000-0003-4952-9709)
- Simone A. Joosten (ORCID: https://orcid.org/0000-0002-9878-0863)
- Robert John Wilkinson (ORCID: https://orcid.org/0000-0002-2753-1800)
- Catherine Riou (ORCID: https://orcid.org/0000-0001-9679-0745)
- Thomas J. Scriba (ORCID: https://orcid.org/0000-0002-0641-1359)
- Krista E. van Meijgaarden (ORCID: https://orcid.org/0000-0003-2818-9805)
- Linda Voogd (ORCID: https://orcid.org/0000-0002-0523-8929)
Institutions
- University of Cape Town (ZA)
- Leiden University Medical Center (NL)
- The Francis Crick Institute (GB)
- South African Tuberculosis Vaccine Initiative (ZA)
- Wellcome Centre for Infectious Diseases Research in Africa (ZA)
- Imperial College London (GB)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-12-23
- DOI
- https://doi.org/10.3389/fimmu.2024.1505329
- Citations
- 1
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 0.24
Funders
- Wellcome
- Francis Crick Institute
- UK Research and Innovation
- Cancer Research UK
- National Institute for Health and Care Research
- Imperial College London
- Leids Universitair Medisch Centrum
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases