Chronic nicotine exposure induces molecular and transcriptomic endophenotypes associated with mood and anxiety disorders in a cerebral organoid neurodevelopmental model
Collectively, our results demonstrate that nicotine-induced alterations occur acutely and persist at later stages of development. These findings validate an <i>in vitro</i> model of PNE to better comprehend the emergence of neuropsychiatric molecular and transcriptomic endophenotypes resulting from gestational nicotine exposure.
Authors
- Daniel B. Hardy (ORCID: https://orcid.org/0000-0001-5445-273X)
- Sebastian Vanin
- Dana Gummerson
- Walter J. Rushlow
- Mar Rodríguez-Ruiz (ORCID: https://orcid.org/0000-0002-1583-5997)
- Emma Proud
- Steven R. Laviolette
Institutions
- Western University (CA)
- Lawson Health Research Institute (CA)
- Children’s Health Research Institute (CA)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2024-12-23
- DOI
- https://doi.org/10.3389/fphar.2024.1473213
- Citations
- 3
- Primary Topic
- Nicotinic Acetylcholine Receptors Study
- Type
- article
- Field-Weighted Citation Impact
- 0.70
Funders
- Canadian Institutes of Health Research
- National Institute of Mental Health