Dynamic changes and prognostic value of glutathione S-transferase alpha in mild cognitive impairment and Alzheimer’s disease

The findings of the study indicated notable differences in GSTα protein levels among patients with MCI and those with AD after a one-year follow-up period. Furthermore, a positive correlation was observed between changes in GST αprotein levels and the decline in both baseline and cognitive function. This suggests that GSTα protein could potentially act as a biomarker for both MCI and AD, offering fresh insights for early detection and intervention strategies.