Enhancing oncolytic virotherapy by extracellular vesicle mediated microRNA reprogramming of the tumour microenvironment
This study demonstrates (i) that arming ORVs with immunomodulatory miRNA is an effective approach to deliver miRNA to myeloid cells within the TME and (ii) that miRNA have the capacity to reverse the tumour promoting properties of TAMs and improve the efficacy of cancer immunotherapies, such as OV.
Authors
- Graham P. Cook (ORCID: https://orcid.org/0000-0003-0223-3652)
- G Migneco (ORCID: https://orcid.org/0000-0003-1476-8128)
- Tyler Barr (ORCID: https://orcid.org/0009-0008-5291-461X)
- Victoria A. Jennings
- John C. Bell (ORCID: https://orcid.org/0000-0002-9083-357X)
- Fiona Errington‐Mais (ORCID: https://orcid.org/0000-0003-2155-534X)
- David Jackson (ORCID: https://orcid.org/0000-0002-0001-7342)
- Susana Banerjee (ORCID: https://orcid.org/0000-0002-8840-7934)
- Christy Ralph (ORCID: https://orcid.org/0000-0001-5581-2987)
- Alan A. Melcher (ORCID: https://orcid.org/0000-0002-2042-3380)
- Nicola Ingram (ORCID: https://orcid.org/0000-0001-5274-8502)
- Samuel Heaton
- Carolina S. Ilkow (ORCID: https://orcid.org/0000-0003-3488-4062)
- Iain A. McNeish (ORCID: https://orcid.org/0000-0002-9387-7586)
- Reah Rumbold-Hall
- Isabelle St Hilare
- Noura Alzamel
- Katrina Reilly
Institutions
- University of Leeds (GB)
- Royal Marsden NHS Foundation Trust (GB)
- Institute of Cancer Research (GB)
- Ottawa Hospital (CA)
- St James's University Hospital (GB)
- Royal Marsden Hospital (GB)
- Ottawa Hospital Research Institute (CA)
- Imperial College London (GB)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-12-23
- DOI
- https://doi.org/10.3389/fimmu.2024.1500570
- Citations
- 5
- Primary Topic
- Virus-based gene therapy research
- Type
- article
- Field-Weighted Citation Impact
- 2.75
Funders
- Cancer Research UK
- Ovarian Cancer Action
- Faculty of Medicine and Health, University of Leeds