Evaluation of the anti-spasmodic activity of essential oils of Ammodaucus leucotrichus fruits and its main chemical component “perillaldehyde” on intestinal smooth muscle contractions of rodents: ex vivo and in silico approaches
In summary, ALEO exhibits myorelaxant and antispasmodic effects by inhibiting muscarinic receptors and calcium channels, which can be attributed to the presence of perillaldehyde. This provides a scientific foundation for the traditional use of <i>A. leucotrichus</i> in treating gastrointestinal disorders and opens up possibilities for developing a more effective and less toxic drug-utilizing perillaldehyde.
Authors
- John P. Giesy (ORCID: https://orcid.org/0000-0003-1931-9962)
- Tarik Harit (ORCID: https://orcid.org/0000-0001-6161-2367)
- Mohammed Aziz
- Sri Nurestri Abd Malek (ORCID: https://orcid.org/0000-0001-6278-8559)
- Mohamed Marghich (ORCID: https://orcid.org/0000-0002-8266-696X)
- Mourad A. M. Aboul‐Soud (ORCID: https://orcid.org/0000-0001-9395-0563)
- Dara Aldisi (ORCID: https://orcid.org/0000-0002-6375-4681)
- Ahmed Karim (ORCID: https://orcid.org/0000-0002-8707-6854)
- Ouafa Amrani
- Leila Beyi
- Abdelhay Addous
Institutions
- Baylor University (US)
- King Saud University (SA)
- University of Saskatchewan (CA)
- Mohamed I University (MA)
- Chouaib Doukkali University (MA)
- Michigan State University (US)
Publication Details
- Journal
- Frontiers in Chemistry
- Published
- 2024-12-23
- DOI
- https://doi.org/10.3389/fchem.2024.1465674
- Citations
- 1
- Primary Topic
- Essential Oils and Antimicrobial Activity
- Type
- article
- Field-Weighted Citation Impact
- 0.35
Funders
- Baylor University
- Chinese Academy of Sciences
- King Saud University
- State Administration of Foreign Experts Affairs
- Nanjing University