Elucidating the mechanism of stigmasterol in acute pancreatitis treatment: insights from network pharmacology and in vitro/in vivo experiments
This study demonstrated that stigmasterol exhibits a significant protective effect aganist AP, at least in part through enhancing acinar cell apoptosis via modulating the ERK signaling pathways.
Authors
- Xiang Xu (ORCID: https://orcid.org/0000-0003-3978-401X)
- Xiuxian Yu
- Ao Wen
- Guang Xin (ORCID: https://orcid.org/0000-0002-1177-0671)
- Chengyu Wan
- Wen Huang (ORCID: https://orcid.org/0000-0002-9772-9492)
- Yu Cao (ORCID: https://orcid.org/0000-0003-4715-7331)
- Fan Li (ORCID: https://orcid.org/0000-0002-5944-3944)
- X. J. Zhao (ORCID: https://orcid.org/0009-0000-6961-3292)
Institutions
- Sichuan University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2024-12-23
- DOI
- https://doi.org/10.3389/fphar.2024.1485915
- Primary Topic
- Pancreatitis Pathology and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Sichuan University
- West China Hospital, Sichuan University