Metabolic Stress Expands Polyfunctional, Proinflammatory Th <sub>17</sub> Cells in Patients With Psoriatic Arthritis for Whom There is Interleukin‐23–Independent Interleukin‐17 Production
We confirmed the abundance of polyfunctional type 17 CD4 and CD8 cells in the inflamed joints of patients with PsA. We demonstrate IL-23-independent expansion of Th<sub>17</sub> cells, for which IL-23 negatively regulates GM-CSF. This may account for therapeutic differences in IL-17 and IL-23 inhibition in patients with PsA or other spondyloarthritides. Polyfunctional IL-17<sup>pos</sup> Th<sub>17</sub> and Th<sub>17</sub>-derived but not Th<sub>1</sub> cells were expanded by metabolic stress, and metabolic stress may itself represent a unique therapeutic target.
Authors
- Jane Goodall (ORCID: https://orcid.org/0000-0002-3761-161X)
- Carmel B. Stober (ORCID: https://orcid.org/0000-0003-2454-7716)
- Marc Veldhoen (ORCID: https://orcid.org/0000-0002-1478-9562)
- Louise Ellis
- J. S. Hill Gaston
Institutions
- Babraham Institute (GB)
- University of Lisbon (PT)
- Cambridge University Hospitals NHS Foundation Trust (GB)
- Bridge University (SS)
- Hospital de Egas Moniz (PT)
- Addenbrooke's Hospital (GB)
- Instituto Gulbenkian de Ciência (PT)
Publication Details
- Journal
- Arthritis & Rheumatology
- Published
- 2024-12-23
- DOI
- https://doi.org/10.1002/art.43095
- Citations
- 2
- Primary Topic
- Psoriasis: Treatment and Pathogenesis
- Type
- article
- Field-Weighted Citation Impact
- 0.48
Funders
- National Institute for Health and Care Research
- NIHR Cambridge Biomedical Research Centre