Characterising the metabolic functionality of the preterm neonatal gut microbiome prior to the onset of necrotising enterocolitis: a pilot study
Before NEC onset, the preterm gut microbiota showed greater metabolic utilisation of amino acids, potentially indicating a shift from predominantly saccharolytic to proteolytic fermentation. Products of amino acid breakdown could therefore act as biomarkers for NEC development. A larger study is warranted, ideally with infants from multiple sites.
Authors
- Christopher James Stewart (ORCID: https://orcid.org/0000-0002-6033-338X)
- Lauren C. Beck (ORCID: https://orcid.org/0000-0002-8470-9679)
- Jonathan A. Chapman (ORCID: https://orcid.org/0000-0003-1068-8278)
- Nicholas David Embleton (ORCID: https://orcid.org/0000-0003-3750-5566)
- Janet Elizabeth Berrington (ORCID: https://orcid.org/0000-0002-6185-2843)
- Tiffany Brown (ORCID: https://orcid.org/0000-0002-5399-3953)
- Emily Wroot
Institutions
- University of Oxford (GB)
- Newcastle upon Tyne Hospital (GB)
- Newcastle University (GB)
Publication Details
- Journal
- BMC Microbiology
- Published
- 2024-12-23
- DOI
- https://doi.org/10.1186/s12866-024-03701-x
- Citations
- 4
- Primary Topic
- Infant Nutrition and Health
- Type
- article
- Field-Weighted Citation Impact
- 1.24
Funders
- Wellcome Trust
- Newcastle University
- Lister Institute of Preventive Medicine