Differential expression of metabolic enzymes in testicular germ cell tumors: The impact of glycolytic metabolism in embryonal carcinoma histotype
We highlighted distinct metabolic profiles among testicular germ cell tumor subtypes, particularly the prominent glycolytic activity in embryonal carcinomas, with higher hypoxia and reliance on lactate transport. Metabolic reprogramming in embryonal carcinoma may underlie the high proliferation of this tumor subtype, which frequently discloses necrosis. These findings suggest that targeted agents such as MCT1 inhibitors may be particularly useful for treating testicular germ cell tumors containing high proportion of embryonal carcinoma.
Authors
- Isaac Braga (ORCID: https://orcid.org/0000-0001-9265-4324)
- Cármen Jerónimo (ORCID: https://orcid.org/0000-0003-4186-5345)
- Vera Miranda‐Gonçalves (ORCID: https://orcid.org/0000-0002-4231-5532)
- Joaquina Maurício
- Rui Henrique (ORCID: https://orcid.org/0000-0003-3171-4666)
- Mariana Cantante
- Nuno Tiago Tavares (ORCID: https://orcid.org/0000-0001-8426-1838)
- Rita de Cássia Avellaneda Guimarães (ORCID: https://orcid.org/0000-0001-9324-7018)
- João Lobo (ORCID: https://orcid.org/0000-0001-6829-1391)
- Andres Acosta (ORCID: https://orcid.org/0000-0002-1324-6312)
Institutions
- Universidade do Porto (PT)
- Instituto Português de Oncologia Francisco Gentil (PT)
- IPO Porto (PT)
- Indiana University Indianapolis (US)
- Indiana University – Purdue University Indianapolis (US)
Publication Details
- Journal
- Andrology
- Published
- 2024-12-22
- DOI
- https://doi.org/10.1111/andr.13824
- Citations
- 2
- Primary Topic
- Testicular diseases and treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.15
Funders
- Fundação para a Ciência e a Tecnologia