ADAM Metallopeptidase domain 19 promotes skin fibrosis in systemic sclerosis via neuregulin-1
ADAM19 plays a role in TGF-β-induced ECM deposition and fibroblast activation by mediating the shedding of NRG1, ultimately contributing to the development of skin fibrosis in SSc.
Authors
- Bingying Dai
- Hui Luo (ORCID: https://orcid.org/0000-0001-5593-8563)
- Qiming Meng (ORCID: https://orcid.org/0009-0001-4304-3997)
- Honglin Zhu (ORCID: https://orcid.org/0000-0002-9322-5684)
- Liqing Ding (ORCID: https://orcid.org/0000-0001-5740-7344)
- Shasha Xie (ORCID: https://orcid.org/0009-0006-7990-8629)
- Muyao Guo (ORCID: https://orcid.org/0000-0003-1347-0848)
- Sijia Liu (ORCID: https://orcid.org/0000-0001-9763-1164)
- Jing Huang (ORCID: https://orcid.org/0000-0002-2167-8385)
- Chunliu Lv
- Meng Meng (ORCID: https://orcid.org/0009-0000-4626-0084)
- Ding Bao
- Weijia He
Institutions
- Central South University (CN)
- Hunan Provincial Center for Disease Control and Prevention (CN)
- Hunan Cancer Hospital (CN)
- Xiangya Hospital Central South University (CN)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2024-12-23
- DOI
- https://doi.org/10.1186/s10020-024-01047-8
- Citations
- 8
- Primary Topic
- Systemic Sclerosis and Related Diseases
- Type
- article
- Field-Weighted Citation Impact
- 3.40
Funders
- National Natural Science Foundation of China
- Central South University
- Natural Science Foundation of Hunan Province
- Xiangya Hospital, Central South University